Traits

Traits linked to WNT1

Wnt family member 1

The Human Phenotype Ontology links 17 traits to WNT1, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the musculoskeletal system

Trait	How often it is seen
Bowing of limbs due to multiple fractures	Always
Recurrent fractures	Always
Bone pain	Very often (80–99%)
Osteoporosis	Very often (80–99%)
Compression fracture of a vertebral body	Often (30–79%)
Double-Jointed	Often (30–79%)
Hunched back	Sometimes (5–29%)
Flattened vertebrae	Not recorded
Scoliosis	Not recorded
Thin ribs	Not recorded

Abnormality of the nervous system

Trait	How often it is seen
Abnormal gait	Often (30–79%)
Global developmental delay	Sometimes (5–29%)
Hypoplasia of the pons	Not recorded
Schizencephaly	Not recorded
Small cerebellum	Not recorded

Abnormality of the eye

Trait	How often it is seen
Blue outer white part of eyeball	Often (30–79%)

Growth abnormality

Trait	How often it is seen
Short stature	Not recorded

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to WNT1 and how often each is seen. Find out more at hpo.jax.org.

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