Traits

Traits linked to TNR

tenascin R

The Human Phenotype Ontology links 24 traits to TNR, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Choreoathetosis	Always
CNS demyelination	Always
Difficulty articulating speech	Always
Generalized dystonia	Always
Inability to walk	Always
Increased reflexes	Always
Motor delay	Always
Delayed speech and language development	Very often (80–99%)
Overactive lower leg reflex	Very often (80–99%)
Apraxia	Often (30–79%)
Delayed CNS myelination	Often (30–79%)
Dystonia	Often (30–79%)
Global developmental delay	Often (30–79%)
Upper limb hyperreflexia	Often (30–79%)
Partial agenesis of the corpus callosum	Sometimes (5–29%)
Thin corpus callosum	Sometimes (5–29%)
Parkinsonism	Not recorded

Abnormality of the musculoskeletal system

Trait	How often it is seen
Spastic tetraparesis	Always
Involuntary muscle stiffness, contraction, or spasm	Very often (80–99%)
Low muscle tone in trunk	Often (30–79%)
Opisthotonus	Often (30–79%)

Abnormality of limbs

Trait	How often it is seen
Distal upper limb amyotrophy	Always
Distal upper limb muscle weakness	Always

Abnormality of the eye

Trait	How often it is seen
Slow eye movements	Always

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to TNR and how often each is seen. Find out more at hpo.jax.org.

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