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Gene

TMPRSS15

transmembrane serine protease 15

Summary

Cytogenetic location
21q21.1
Coordinates
Chromosome 21: 18,269,116–18,403,785 (GRCh38)
Exons
25 exons across 134.7 kb
Protein
1,019 amino acids
Inheritance
Autosomal recessive
Also known as
ENTK, MGC133046
Previous symbols
PRSS7
MANE Select transcript
ENST00000284885.8NM_002772.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Congenital Diarrhoeas & Enteropathies

    • Congenital enteropathy due to enteropeptidase deficiencyAutosomal recessive

      A deficiency of the intestinal enzyme enteropeptidase, caused by TMPRSS15 variants, that prevents activation of pancreatic digestive enzymes.

      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      Pancreatic enzyme replacement is effective.

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How TMPRSS15 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 21, with a bracket where TMPRSS15 sits. TMPRSS15 and 1 gene near it on chromosome 21, from 17,836,451 to 18,836,450.Chromosome 2121q21.1p13p12p11.2p11.1q11.1q11.2q21.1q21.2q21.3q22.11q22.12q22.13q22.2q22.318 Mb18.2 Mb18.4 Mb18.6 Mb18.8 MbCHODL: 17,901,263–18,270,231, forward strandCHODLTMPRSS15: 18,269,116–18,403,785, reverse strandTMPRSS15Diagram of TMPRSS15: 25 exons on the reverse strand of chromosome 21Exon 22: 3 known disease-causing sitesExon 21: 1 known disease-causing siteExon 20: 1 known disease-causing siteExon 18: 3 known disease-causing sitesExon 13: 1 known disease-causing siteExon 12: 1 known disease-causing siteExon 10: 1 known disease-causing siteExon 8: 3 known disease-causing sitesExon 3: 1 known disease-causing siteExon 2: 1 known disease-causing siteExon 1: 1 known disease-causing siteExon 25: 18,269,116–18,270,124, 1,009 basesExon 24: 18,275,197–18,275,336, 140 basesExon 23: 18,278,964–18,279,059, 96 basesExon 22: 18,281,040–18,281,221, 182 basesExon 21: 18,294,270–18,294,444, 175 basesExon 20: 18,294,603–18,294,652, 50 basesExon 19: 18,297,734–18,297,829, 96 basesExon 18: 18,312,945–18,313,077, 133 basesExon 17: 18,315,146–18,315,256, 111 basesExon 16: 18,326,432–18,326,572, 141 basesExon 15: 18,329,169–18,329,294, 126 basesExon 14: 18,332,084–18,332,173, 90 basesExon 13: 18,341,413–18,341,548, 136 basesExon 12: 18,343,506–18,343,656, 151 basesExon 11: 18,343,955–18,344,060, 106 basesExon 10: 18,352,903–18,353,052, 150 basesExon 9: 18,353,723–18,353,863, 141 basesExon 8: 18,359,757–18,359,863, 107 basesExon 7: 18,365,140–18,365,248, 109 basesExon 6: 18,372,193–18,372,324, 132 basesExon 5: 18,379,283–18,379,318, 36 basesExon 4: 18,383,627–18,383,778, 152 basesExon 3: 18,397,879–18,397,946, 68 basesExon 2: 18,398,199–18,398,329, 131 basesExon 1: 18,403,478–18,403,785, 308 bases252422201816141210864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.1 kb of the gene's 134.7 kb; 3,060 of those bases code for the protein.

How a genome test reads TMPRSS15

19

positions in TMPRSS15 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 134.7 kb of TMPRSS15, introns included, not only the 4.1 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TMPRSS15 gene: transmembrane serine protease 15. Retrieved 16 October 2026, from https://dantelabs.com/genes/tmprss15

Vancouver

Dante Labs. TMPRSS15 gene: transmembrane serine protease 15 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/tmprss15

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