Traits

Traits linked to NGF

nerve growth factor

The Human Phenotype Ontology links 26 traits to NGF, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Impaired pain sensation	Always
Pain insensitivity	Always
Peripheral neuropathy	Always
Decreased number of small peripheral myelinated nerve fibers	Often (30–79%)
Hand tremor	Often (30–79%)
Impaired temperature sensation	Often (30–79%)
Impaired vibratory sensation	Often (30–79%)
Intellectual disability, mild	Often (30–79%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Painless fractures due to injury	Always
Degenerative joint disease	Often (30–79%)
Disease of the joints	Often (30–79%)
Infected joint	Often (30–79%)
Lumbago	Often (30–79%)
Recurrent fractures	Often (30–79%)

Abnormality of head or neck

Trait	How often it is seen
Abnormal dentition	Often (30–79%)
Abnormality of the gums	Often (30–79%)
Zygomatic flattening	Often (30–79%)

Abnormality of the integument

Trait	How often it is seen
Lack of sweating	Often (30–79%)
Poor wound healing	Often (30–79%)
Acral ulceration	Not recorded

Abnormality of the digestive system

Trait	How often it is seen
Constipation	Often (30–79%)
Diarrhea	Often (30–79%)

Abnormality of the eye

Trait	How often it is seen
Deeply set eye	Often (30–79%)

Abnormality of the genitourinary system

Trait	How often it is seen
Loss of bladder control	Often (30–79%)

Abnormality of the immune system

Trait	How often it is seen
Bone infection	Not recorded

Laboratory abnormality

Trait	How often it is seen
Episodic fever	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to NGF and how often each is seen. Find out more at hpo.jax.org.

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