Traits

Traits linked to MYH9

myosin heavy chain 9

The Human Phenotype Ontology links 26 traits to MYH9, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Giant platelets	Always
Impaired ADP-induced platelet aggregation	Always
Impaired epinephrine-induced platelet aggregation	Always
Leukocyte inclusion bodies	Always
Low platelet count	Always
Macrothrombocytopenia	Always
Megakaryocyte dysplasia	Always
Neutrophil inclusion bodies	Always
Congenital thrombocytopenia	Very often (80–99%)
Abnormally heavy bleeding during menstruation	Often (30–79%)
Bruising susceptibility	Often (30–79%)
Large platelets	Often (30–79%)
Prolonged bleeding time	Often (30–79%)
Recurring nosebleed	Often (30–79%)
Abnormal blood clot	Not recorded
Bleeding tendency	Not recorded
Bloody nose	Not recorded

Abnormality of the genitourinary system

Trait	How often it is seen
Kidney damage	Often (30–79%)
Kidney inflammation	Often (30–79%)
Renal failure	Often (30–79%)

Abnormality of the ear

Trait	How often it is seen
Sensorineural hearing impairment	Often (30–79%)
Hearing loss, high-frequency	Not recorded

Laboratory abnormality

Trait	How often it is seen
High liver enzymes	Often (30–79%)
High urine protein levels	Often (30–79%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Heart attack	Rarely (1–4%)

Abnormality of the eye

Trait	How often it is seen
Presenile cataracts	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to MYH9 and how often each is seen. Find out more at hpo.jax.org.

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