Traits

Traits linked to LSM7

LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated

The Human Phenotype Ontology links 25 traits to LSM7, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Age-inappropriate oppositional behavior	Always
Anxiety	Always
Apraxia	Always
Ataxia	Always
Balance impairment	Always
Extrapyramidal dyskinesia	Always
Global developmental delay	Always
Intellectual disability	Always
Leukodystrophy	Always
Small cerebellum	Always
Tetraparesis	Always
Tremor	Always

Abnormality of the musculoskeletal system

Trait	How often it is seen
Involuntary muscle stiffness, contraction, or spasm	Always
Low muscle tone in trunk	Always
Spastic tetraparesis	Always

Abnormality of head or neck

Trait	How often it is seen
Encephalocele	Always
Increased nuchal translucency	Always

Abnormality of the digestive system

Trait	How often it is seen
Feeding difficulties	Always
Jaundice	Always

Abnormality of the eye

Trait	How often it is seen
Cross-eyed	Always
Involuntary, rapid, rhythmic eye movements	Always

Abnormality of prenatal development or birth

Trait	How often it is seen
Premature birth	Always

Abnormality of the ear

Trait	How often it is seen
Sensorineural hearing impairment	Often (30–79%)

Abnormality of the genitourinary system

Trait	How often it is seen
Hypospadias	Often (30–79%)

Abnormality of the respiratory system

Trait	How often it is seen
Breathing difficulties	Always

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to LSM7 and how often each is seen. Find out more at hpo.jax.org.

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