Traits

Traits linked to KIF12

kinesin family member 12

The Human Phenotype Ontology links 19 traits to KIF12, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the digestive system

Trait	How often it is seen
Jaundice	Always
Slowed or blocked flow of bile from liver	Always
Bile duct proliferation	Very often (80–99%)
Hepatic fibrosis	Very often (80–99%)
Enlarged liver	Often (30–79%)
Hepatic bridging fibrosis	Often (30–79%)
Scar tissue replaces healthy tissue in the liver	Often (30–79%)
Enlarged vein in esophagus	Sometimes (5–29%)
Sclerosing cholangitis	Sometimes (5–29%)

Laboratory abnormality

Trait	How often it is seen
Elevated alkaline phosphatase	Always
Elevated circulating alanine aminotransferase concentration	Always
Elevated circulating aspartate aminotransferase concentration	Always
Elevated gamma-glutamyltransferase level	Always
Increased serum bile acid concentration	Always
Conjugated hyperbilirubinemia	Often (30–79%)
Elevated circulating alpha-fetoprotein concentration	Often (30–79%)
Elevated serum cholesterol	Often (30–79%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Portal hypertension	Sometimes (5–29%)

Abnormality of the integument

Trait	How often it is seen
Itching	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to KIF12 and how often each is seen. Find out more at hpo.jax.org.

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test