Traits

Traits linked to IQSEC1

IQ motif and Sec7 domain ArfGEF 1

The Human Phenotype Ontology links 14 traits to IQSEC1, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Global developmental delay	Always
Intellectual disability, severe	Always
Motor delay	Always
Absent speech development	Often (30–79%)
Aggressive behavior	Often (30–79%)
Attention deficit	Often (30–79%)
Delayed ability to walk	Often (30–79%)
Epilepsy	Often (30–79%)
Repeated seizures without recovery between them	Often (30–79%)
Inability to coordinate movements when walking	Sometimes (5–29%)

Abnormality of head or neck

Trait	How often it is seen
Abnormally small head	Often (30–79%)

Abnormality of the eye

Trait	How often it is seen
Visual impairment	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Generalized decreased muscle tone	Always

Growth abnormality

Trait	How often it is seen
Short stature	Always

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to IQSEC1 and how often each is seen. Find out more at hpo.jax.org.

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test