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Gene

IQSEC1

IQ motif and Sec7 domain ArfGEF 1

Summary

Cytogenetic location
3p25.2
Coordinates
Chromosome 3: 12,897,043–13,073,429 (GRCh38)
Exons
14 exons across 176.4 kb
Protein
1,114 amino acids
Also known as
KIAA0763, GEP100, BRAG2, ARF-GEP100
MANE Select transcript
ENST00000613206.2NM_001134382.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads IQSEC1 yet. The test sequences your whole genome, so your data includes it all the same.

How IQSEC1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 3, with a bracket where IQSEC1 sits. IQSEC1 and 10 genes near it on chromosome 3, from 12,485,236 to 13,485,235.Chromosome 33p25.2p26.3p26.2p26.1p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13.11q13.12q13.13q13.2q13.31q13.32q13.33q21.1q21.2q21.3q22.1q22.2q22.3q23q24q25.1q25.2q25.31q25.32q25.33q26.1q26.2q26.31q26.32q26.33q27.1q27.2q27.3q28q2912.6 Mb12.8 Mb13 Mb13.2 Mb13.4 MbTSEN2: 12,480,529–12,541,549, forward strandTSEN2MKRN2OS: 12,514,934–12,561,059, reverse strandMKRN2OSMKRN2: 12,557,011–12,603,555, forward strandMKRN2RAF1: 12,582,101–12,664,201, reverse strandRAF1TMEM40: 12,733,528–12,769,457, reverse strandTMEM40CAND2: 12,796,472–12,836,433, forward strandCAND2: 12,825,768–12,871,919, forward strandRPL32: 12,834,467–12,841,587, reverse strandRPL32IQSEC1: 12,897,043–13,073,429, reverse strandIQSEC1NUP210: 13,316,231–13,420,395, reverse strandNUP210HDAC11: 13,479,724–13,506,424, forward strandHDAC11Diagram of IQSEC1: 14 exons on the reverse strand of chromosome 3Exon 3: 1 known disease-causing siteExon 14: 12,897,043–12,901,522, 4,480 basesExon 13: 12,902,773–12,902,822, 50 basesExon 12: 12,908,349–12,908,525, 177 basesExon 11: 12,909,273–12,909,434, 162 basesExon 10: 12,911,629–12,911,728, 100 basesExon 9: 12,913,428–12,913,553, 126 basesExon 8: 12,915,104–12,915,133, 30 basesExon 7: 12,915,594–12,915,733, 140 basesExon 6: 12,920,430–12,920,596, 167 basesExon 5: 12,922,120–12,922,242, 123 basesExon 4: 12,924,581–12,924,742, 162 basesExon 3: 12,935,448–12,936,697, 1,250 basesExon 2: 12,941,571–12,941,865, 295 basesExon 1: 13,072,992–13,073,429, 438 bases1410515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 7.7 kb of the gene's 176.4 kb; 3,345 of those bases code for the protein.

How a genome test reads IQSEC1

1

position in IQSEC1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 176.4 kb of IQSEC1, introns included, not only the 7.7 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). IQSEC1 gene: IQ motif and Sec7 domain ArfGEF 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/iqsec1

Vancouver

Dante Labs. IQSEC1 gene: IQ motif and Sec7 domain ArfGEF 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/iqsec1

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