Traits

Traits linked to CD3E

CD3 epsilon subunit of T-cell receptor complex

The Human Phenotype Ontology links 31 traits to CD3E, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the immune system

Trait	How often it is seen
Decreased immune function	Always
Recurrent pneumonia	Always
Recurrent infections	Very often (80–99%)
Pneumonia	Sometimes (5–29%)
Recurrent abscess formation	Sometimes (5–29%)
Recurrent Candida infection	Sometimes (5–29%)
Red scaly skin caused by inflammatory skin disease	Sometimes (5–29%)
Susceptibility to herpesvirus	Sometimes (5–29%)
Recurrent respiratory infections	Not recorded

Abnormal cellular phenotype

Trait	How often it is seen
Abnormal T cell proliferation	Always
Chronic decreased circulating IgA concentration	Always
Decreased circulating IgG concentration	Often (30–79%)
Decreased circulating IgM concentration	Often (30–79%)
Decreased mitogen-induced T-cell proliferation	Often (30–79%)
Increased antibody level in blood	Sometimes (5–29%)

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Abnormal lymphocyte count	Always
Decreased blood lymphocyte number	Always
Decreased total CD4+ T cell proportion	Always
Low T cell count	Always
High blood eosinophil count	Sometimes (5–29%)

Abnormality of the digestive system

Trait	How often it is seen
Anorexia	Sometimes (5–29%)
Diarrhea	Sometimes (5–29%)
Liver inflammation	Sometimes (5–29%)
Protracted diarrhea	Sometimes (5–29%)
Recurrent gastroenteritis	Not recorded

Abnormality of the ear

Trait	How often it is seen
Recurrent middle ear infection	Always
Middle ear infection	Sometimes (5–29%)

Abnormality of head or neck

Trait	How often it is seen
Chronic oral thrush	Sometimes (5–29%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Enlarged liver and spleen	Sometimes (5–29%)

Growth abnormality

Trait	How often it is seen
Faltering weight secondary to recurrent infections	Often (30–79%)

Laboratory abnormality

Trait	How often it is seen
Fever	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to CD3E and how often each is seen. Find out more at hpo.jax.org.

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