Traits

Traits linked to CD3D

CD3 delta subunit of T-cell receptor complex

The Human Phenotype Ontology links 29 traits to CD3D, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the immune system

Trait	How often it is seen
Severe combined immunodeficiency	Always
Severe viral infection	Always
Recurrent infections	Very often (80–99%)
Pneumonia	Sometimes (5–29%)
Recurrent abscess formation	Sometimes (5–29%)
Recurrent Candida infection	Sometimes (5–29%)
Recurrent pneumonia	Sometimes (5–29%)
Red scaly skin caused by inflammatory skin disease	Sometimes (5–29%)
Susceptibility to herpesvirus	Sometimes (5–29%)
Recurrent respiratory infections	Not recorded

Abnormality of the digestive system

Trait	How often it is seen
Chronic diarrhea	Often (30–79%)
Anorexia	Sometimes (5–29%)
Diarrhea	Sometimes (5–29%)
Liver inflammation	Sometimes (5–29%)
Protracted diarrhea	Sometimes (5–29%)

Abnormal cellular phenotype

Trait	How often it is seen
Chronic decreased circulating IgA concentration	Often (30–79%)
Decreased circulating IgG concentration	Often (30–79%)
Decreased mitogen-induced T-cell proliferation	Often (30–79%)
Increased antibody level in blood	Sometimes (5–29%)

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Low T cell count	Always
Decreased blood lymphocyte number	Often (30–79%)
High blood eosinophil count	Sometimes (5–29%)

Abnormality of the ear

Trait	How often it is seen
Middle ear infection	Sometimes (5–29%)
Recurrent middle ear infection	Not recorded

Growth abnormality

Trait	How often it is seen
Faltering weight secondary to recurrent infections	Often (30–79%)
Faltering weight	Not recorded

Abnormality of head or neck

Trait	How often it is seen
Chronic oral thrush	Sometimes (5–29%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Enlarged liver and spleen	Sometimes (5–29%)

Laboratory abnormality

Trait	How often it is seen
Fever	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to CD3D and how often each is seen. Find out more at hpo.jax.org.

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