Traits

Traits linked to BACH2

BACH transcriptional regulator 2

The Human Phenotype Ontology links 18 traits to BACH2, by body system: features seen in people with one of the gene's rare conditions.

Abnormal cellular phenotype

Trait	How often it is seen
Decreased circulating IgA concentration	Always
Decreased circulating IgE concentration	Often (30–79%)
Decreased circulating IgG concentration	Often (30–79%)
Decreased circulating IgM concentration	Often (30–79%)

Abnormality of the digestive system

Trait	How often it is seen
Chronic diarrhea	Always
Crohn's disease	Often (30–79%)
Ulcerative colitis	Often (30–79%)
Colitis	Not recorded

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Decreased memory B cell proportion	Always
Decreased total basophil count	Always
Low blood cell count	Not recorded

Abnormality of the respiratory system

Trait	How often it is seen
Permanent enlargement of the airways of the lungs	Often (30–79%)
Lung infiltrates	Not recorded
Pulmonary scarring	Not recorded

Abnormality of the immune system

Trait	How often it is seen
Recurrent sinus and lung infections	Always
Perinuclear antineutrophil antibody positivity	Often (30–79%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Increased spleen size	Not recorded

Laboratory abnormality

Trait	How often it is seen
Fever	Not recorded

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to BACH2 and how often each is seen. Find out more at hpo.jax.org.

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