Traits

Traits linked to ADAM22

ADAM metallopeptidase domain 22

The Human Phenotype Ontology links 17 traits to ADAM22, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Bilateral tonic-clonic seizure with focal onset	Always
Degeneration of cerebrum	Always
Epilepsy	Always
Focal clonic seizure	Always
IQ less than 20	Always
Loss of ability to walk	Always
Poor eye contact	Always
Epileptic encephalopathy	Not recorded

Abnormality of head or neck

Trait	How often it is seen
Development of small head that was not present at birth	Always
Full lips	Always
High palate	Always
Narrow forehead	Always
Open mouth	Always

Abnormality of the musculoskeletal system

Trait	How often it is seen
Generalized decreased muscle tone	Always
Involuntary muscle stiffness, contraction, or spasm	Not recorded

Abnormality of the eye

Trait	How often it is seen
Optic atrophy	Always

Abnormality of the respiratory system

Trait	How often it is seen
Apnea	Always

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to ADAM22 and how often each is seen. Find out more at hpo.jax.org.

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