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Trait

Elevated blood renin level

Clinical name: Increased circulating renin concentration

An increased level of renin in the blood.

HPO HP:0000848

Summary

Also called
Elevated plasma renin, Hyperreninemia, Increased circulating renin level, Increased plasma renin, Increased serum renin
Body system
Abnormality of the endocrine system

19 genes linked to Elevated blood renin level

Changes in these genes cause rare conditions in which Elevated blood renin level is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
KCNJ1potassium inwardly rectifying channel subfamily J member 1AlwaysIn 1 condition
KCNJ16potassium inwardly rectifying channel subfamily J member 16AlwaysIn 1 condition
SCNN1Gsodium channel epithelial 1 subunit gammaAlwaysIn 2 conditions
SLC26A3solute carrier family 26 member 3AlwaysIn 1 condition
BSNDbarttin CLCNK type accessory subunit betaVery often (80–99%)In 1 condition
CLCNKAchloride voltage-gated channel KaVery often (80–99%)In 1 condition
CLCNKBchloride voltage-gated channel KbVery often (80–99%)In 2 conditions
CYP11A1cytochrome P450 family 11 subfamily A member 1Very often (80–99%)In 2 conditions
KCNJ10potassium inwardly rectifying channel subfamily J member 10Very often (80–99%)In 2 conditions
SCNN1Asodium channel epithelial 1 subunit alphaVery often (80–99%)In 1 condition
SCNN1Bsodium channel epithelial 1 subunit betaVery often (80–99%)In 2 conditions
CYP11B2cytochrome P450 family 11 subfamily B member 2Often (30–79%)In 3 conditions
HSD3B2hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2Often (30–79%)In 1 condition
CASRcalcium sensing receptorSometimes (5–29%)In 1 condition
INSRinsulin receptorSometimes (5–29%)In 1 condition
MAGED2MAGE family member D2Not recordedIn 1 condition
NR3C2nuclear receptor subfamily 3 group C member 2Not recordedIn 1 condition
SLC12A1solute carrier family 12 member 1Not recordedIn 1 condition
SLC12A3solute carrier family 12 member 3Not recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormal circulating renin

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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