{
  "url": "https://dantelabs.com/traits/hypoinsulinemia",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "hypoinsulinemia",
    "id": "HP:0040216",
    "name": "Hypoinsulinemia",
    "definition": "A decreased concentration of insulin in the blood.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-endocrine-system",
        "name": "Abnormality of the endocrine system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-endocrine-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-circulating-insulin-concentration",
        "name": "Abnormal circulating insulin concentration",
        "url": "https://dantelabs.com/traits/abnormal-circulating-insulin-concentration"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "akt2",
        "symbol": "AKT2",
        "hgnc": "HGNC:392",
        "name": "AKT serine/threonine kinase 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/akt2"
      },
      {
        "slug": "pax4",
        "symbol": "PAX4",
        "hgnc": "HGNC:8618",
        "name": "paired box 4",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/pax4"
      },
      {
        "slug": "pcsk1",
        "symbol": "PCSK1",
        "hgnc": "HGNC:8743",
        "name": "proprotein convertase subtilisin/kexin type 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pcsk1"
      },
      {
        "slug": "abcc8",
        "symbol": "ABCC8",
        "hgnc": "HGNC:59",
        "name": "ATP binding cassette subfamily C member 8",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/abcc8"
      },
      {
        "slug": "hymai",
        "symbol": "HYMAI",
        "hgnc": "HGNC:5326",
        "name": "hydatidiform mole associated and imprinted",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hymai"
      },
      {
        "slug": "kcnj11",
        "symbol": "KCNJ11",
        "hgnc": "HGNC:6257",
        "name": "potassium inwardly rectifying channel subfamily J member 11",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/kcnj11"
      },
      {
        "slug": "plagl1",
        "symbol": "PLAGL1",
        "hgnc": "HGNC:9046",
        "name": "PLAG1 like zinc finger 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/plagl1"
      },
      {
        "slug": "zfp57",
        "symbol": "ZFP57",
        "hgnc": "HGNC:18791",
        "name": "ZFP57 zinc finger protein",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zfp57"
      },
      {
        "slug": "appl1",
        "symbol": "APPL1",
        "hgnc": "HGNC:24035",
        "name": "adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/appl1"
      },
      {
        "slug": "blk",
        "symbol": "BLK",
        "hgnc": "HGNC:1057",
        "name": "BLK proto-oncogene, Src family tyrosine kinase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/blk"
      },
      {
        "slug": "cel",
        "symbol": "CEL",
        "hgnc": "HGNC:1848",
        "name": "carboxyl ester lipase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cel"
      },
      {
        "slug": "gck",
        "symbol": "GCK",
        "hgnc": "HGNC:4195",
        "name": "glucokinase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gck"
      },
      {
        "slug": "hnf1a",
        "symbol": "HNF1A",
        "hgnc": "HGNC:11621",
        "name": "HNF1 homeobox A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hnf1a"
      },
      {
        "slug": "hnf4a",
        "symbol": "HNF4A",
        "hgnc": "HGNC:5024",
        "name": "hepatocyte nuclear factor 4 alpha",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hnf4a"
      },
      {
        "slug": "ins",
        "symbol": "INS",
        "hgnc": "HGNC:6081",
        "name": "insulin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ins"
      },
      {
        "slug": "klf11",
        "symbol": "KLF11",
        "hgnc": "HGNC:11811",
        "name": "KLF transcription factor 11",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/klf11"
      },
      {
        "slug": "neurod1",
        "symbol": "NEUROD1",
        "hgnc": "HGNC:7762",
        "name": "neuronal differentiation 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/neurod1"
      },
      {
        "slug": "pdx1",
        "symbol": "PDX1",
        "hgnc": "HGNC:6107",
        "name": "pancreatic and duodenal homeobox 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pdx1"
      },
      {
        "slug": "dmxl2",
        "symbol": "DMXL2",
        "hgnc": "HGNC:2938",
        "name": "Dmx like 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dmxl2"
      },
      {
        "slug": "rnf125",
        "symbol": "RNF125",
        "hgnc": "HGNC:21150",
        "name": "ring finger protein 125",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnf125"
      },
      {
        "slug": "nab2",
        "symbol": "NAB2",
        "hgnc": "HGNC:7627",
        "name": "NGFI-A binding protein 2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nab2"
      },
      {
        "slug": "stat6",
        "symbol": "STAT6",
        "hgnc": "HGNC:11368",
        "name": "signal transducer and activator of transcription 6",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stat6"
      }
    ]
  }
}