{
  "url": "https://dantelabs.com/traits/abnormality-of-mental-function",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "abnormality-of-mental-function",
    "id": "HP:0011446",
    "name": "Abnormality of mental function",
    "definition": "Cognitive, psychiatric, or memory anomaly.",
    "synonyms": [
      "Abnormality of higher mental function"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-nervous-system-physiology",
        "name": "Abnormal nervous system physiology",
        "url": "https://dantelabs.com/traits/abnormal-nervous-system-physiology"
      }
    ],
    "narrower": [
      {
        "slug": "intellectual-disability",
        "name": "Intellectual disability",
        "genes": 1647,
        "url": "https://dantelabs.com/traits/intellectual-disability"
      },
      {
        "slug": "atypical-behavior",
        "name": "Behavioral abnormality",
        "genes": 485,
        "url": "https://dantelabs.com/traits/atypical-behavior"
      },
      {
        "slug": "cognitive-impairment",
        "name": "Cognitive impairment",
        "genes": 407,
        "url": "https://dantelabs.com/traits/cognitive-impairment"
      },
      {
        "slug": "sleep-disturbance",
        "name": "Difficulty sleeping",
        "genes": 343,
        "url": "https://dantelabs.com/traits/sleep-disturbance"
      },
      {
        "slug": "reduced-consciousness",
        "name": "Disturbances of consciousness",
        "genes": 37,
        "url": "https://dantelabs.com/traits/reduced-consciousness"
      },
      {
        "slug": "micrographia",
        "name": "Micrographia",
        "genes": 21,
        "url": "https://dantelabs.com/traits/micrographia"
      },
      {
        "slug": "abnormal-affect",
        "name": "Abnormal affect",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-affect"
      },
      {
        "slug": "abnormal-cognitive-process",
        "name": "Abnormal cognitive process",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-cognitive-process"
      },
      {
        "slug": "abnormal-experience-of-reality",
        "name": "Abnormal experience of reality",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-experience-of-reality"
      }
    ],
    "genes": [
      {
        "slug": "acat1",
        "symbol": "ACAT1",
        "hgnc": "HGNC:93",
        "name": "acetyl-CoA acetyltransferase 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/acat1"
      },
      {
        "slug": "atp13a2",
        "symbol": "ATP13A2",
        "hgnc": "HGNC:30213",
        "name": "ATPase cation transporting 13A2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp13a2"
      },
      {
        "slug": "spg7",
        "symbol": "SPG7",
        "hgnc": "HGNC:11237",
        "name": "SPG7 matrix AAA peptidase subunit, paraplegin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spg7"
      },
      {
        "slug": "app",
        "symbol": "APP",
        "hgnc": "HGNC:620",
        "name": "amyloid beta precursor protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/app"
      },
      {
        "slug": "galt",
        "symbol": "GALT",
        "hgnc": "HGNC:4135",
        "name": "galactose-1-phosphate uridylyltransferase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/galt"
      },
      {
        "slug": "men1",
        "symbol": "MEN1",
        "hgnc": "HGNC:7010",
        "name": "menin 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/men1"
      },
      {
        "slug": "prnp",
        "symbol": "PRNP",
        "hgnc": "HGNC:9449",
        "name": "prion protein (Kanno blood group)",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prnp"
      },
      {
        "slug": "psen1",
        "symbol": "PSEN1",
        "hgnc": "HGNC:9508",
        "name": "presenilin 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/psen1"
      },
      {
        "slug": "psen2",
        "symbol": "PSEN2",
        "hgnc": "HGNC:9509",
        "name": "presenilin 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/psen2"
      },
      {
        "slug": "reep2",
        "symbol": "REEP2",
        "hgnc": "HGNC:17975",
        "name": "receptor accessory protein 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/reep2"
      },
      {
        "slug": "sorl1",
        "symbol": "SORL1",
        "hgnc": "HGNC:11185",
        "name": "sortilin related receptor 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sorl1"
      },
      {
        "slug": "tomm40",
        "symbol": "TOMM40",
        "hgnc": "HGNC:18001",
        "name": "translocase of outer mitochondrial membrane 40",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tomm40"
      },
      {
        "slug": "trem2",
        "symbol": "TREM2",
        "hgnc": "HGNC:17761",
        "name": "triggering receptor expressed on myeloid cells 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trem2"
      },
      {
        "slug": "yy1",
        "symbol": "YY1",
        "hgnc": "HGNC:12856",
        "name": "YY1 transcription factor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/yy1"
      },
      {
        "slug": "crppa",
        "symbol": "CRPPA",
        "hgnc": "HGNC:37276",
        "name": "CDP-L-ribitol pyrophosphorylase A",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/crppa"
      }
    ]
  }
}