Traits

Traits linked to ZNF668

zinc finger protein 668

The Human Phenotype Ontology links 28 traits to ZNF668, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of head or neck

Trait	How often it is seen
Abnormally small head	Always
Prominent nose	Always
Big maxilla	Often (30–79%)
High palate	Often (30–79%)
Little lower jaw	Often (30–79%)
Skin tag in front of the ear	Often (30–79%)

Abnormality of the nervous system

Trait	How often it is seen
Global developmental delay	Always
Intellectual disability	Always
Brain degeneration	Often (30–79%)
Epilepsy	Often (30–79%)
Epileptic encephalopathy	Often (30–79%)

Abnormality of limbs

Trait	How often it is seen
Long big toe	Always
Broad thumb	Often (30–79%)
Bunion	Often (30–79%)
Curvature of digit	Often (30–79%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Low muscle tone	Always
Lower limb spasticity	Often (30–79%)
Osteopenia	Often (30–79%)
Pigeon chest	Often (30–79%)

Abnormality of the eye

Trait	How often it is seen
Birth defect that causes a hole in the innermost layer at the back of the eye	Often (30–79%)
Deeply set eye	Often (30–79%)

Growth abnormality

Trait	How often it is seen
Faltering weight	Always
Small for gestational age	Always

Abnormality of the cardiovascular system

Trait	How often it is seen
Secundum atrial septal defect	Often (30–79%)

Abnormality of the digestive system

Trait	How often it is seen
Feeding difficulties	Often (30–79%)

Abnormality of the ear

Trait	How often it is seen
Large ears	Always

Abnormality of the immune system

Trait	How often it is seen
Recurrent chest infections	Often (30–79%)

Laboratory abnormality

Trait	How often it is seen
Diabetes mellitus	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to ZNF668 and how often each is seen. Find out more at hpo.jax.org.

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test