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Gene

TRIOBP

TRIO and F-actin binding protein

Summary

Cytogenetic location
22q13.1
Coordinates
Chromosome 22: 37,697,048–37,776,556 (GRCh38)
Exons
24 exons across 79.5 kb
Protein
2,365 amino acids
Also known as
HRIHFB2122, KIAA1662, Tara, TAP68
Previous symbols
DFNB28
MANE Select transcript
ENST00000644935.1NM_001039141.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Hearing Loss and Deafness

      • Nonsyndromic Genetic Hearing Loss

        One of 97 genes linked to it

        Inherited hearing loss without other medical features, including the common recessive forms caused by GJB2, OTOF, SLC26A4, STRC and many other genes, as well as dominant, X-linked and mitochondrial forms.

        • ClinGen rates the link definitive
        • 4 GenCC submitters rate it definitive or strong
        What knowing changes

        Knowing the genetic cause can guide hearing support and cochlear implant decisions, gene-therapy trial eligibility (for example OTOF) and family counselling.

    How TRIOBP is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 22, with a bracket where TRIOBP sits. TRIOBP and 29 genes near it on chromosome 22, from 37,236,802 to 38,236,801.Chromosome 2222q13.1p13p12p11.2p11.1q11.1q11.21q11.22q11.23q12.1q12.2q12.3q13.1q13.2q13.31q13.32q13.3337.4 Mb37.6 Mb37.8 Mb38 Mb38.2 MbRAC2: 37,225,270–37,259,594, reverse strandRAC2CYTH4: 37,282,027–37,315,346, forward strandCYTH4ELFN2: 37,367,960–37,427,596, reverse strandELFN2MFNG: 37,464,544–37,486,432, reverse strandMFNGCARD10: 37,490,362–37,519,591, reverse strandCARD10CDC42EP1: 37,555,112–37,571,052, forward strandCDC42EP1LGALS2: 37,570,246–37,582,616, reverse strandLGALS2GGA1: 37,608,474–37,633,564, forward strandGGA1SH3BP1: 37,634,654–37,656,117, forward strand: 37,639,693–37,666,932, forward strandPDXP: 37,658,715–37,666,934, forward strandPDXPLGALS1: 37,675,587–37,683,414, forward strandLGALS1NOL12: 37,681,673–37,693,476, forward strandNOL12: 37,686,414–37,726,503, forward strandTRIOBP: 37,697,048–37,776,556, forward strandTRIOBPH1-0: 37,805,229–37,807,432, forward strandH1-0GCAT: 37,807,872–37,817,386, forward strandGCATGALR3: 37,822,198–37,825,851, forward strandGALR3ANKRD54: 37,830,853–37,849,327, reverse strandANKRD54EIF3L: 37,848,868–37,889,407, forward strandEIF3LMICALL1: 37,905,657–37,942,822, forward strandMICALL1C22orf23: 37,943,050–37,953,669, reverse strandC22orf23POLR2F: 37,952,607–38,041,932, forward strandPOLR2FSOX10: 37,970,686–37,987,422, reverse strandSOX10PICK1: 38,056,311–38,076,050, forward strandPICK1SLC16A8: 38,078,134–38,084,186, reverse strandSLC16A8BAIAP2L2: 38,084,652–38,111,015, reverse strandBAIAP2L2PLA2G6: 38,111,495–38,214,778, reverse strandPLA2G6MAFF: 38,200,767–38,219,321, forward strandMAFFTMEM184B: 38,215,914–38,273,805, reverse strandTMEM184BDiagram of TRIOBP: 24 exons on the forward strand of chromosome 22Exon 4: 3 known disease-causing sitesExon 5: 1 known disease-causing siteExon 7: 44 known disease-causing sitesExon 8: 1 known disease-causing siteExon 9: 9 known disease-causing sitesExon 11: 1 known disease-causing siteExon 16: 1 known disease-causing siteExon 20: 1 known disease-causing siteExon 1: 37,697,048–37,697,089, 42 basesExon 2: 37,697,588–37,697,696, 109 basesExon 3: 37,701,306–37,701,479, 174 basesExon 4: 37,710,427–37,710,566, 140 basesExon 5: 37,713,210–37,713,411, 202 basesExon 6: 37,715,763–37,715,934, 172 basesExon 7: 37,723,185–37,726,503, 3,319 basesExon 8: 37,733,298–37,733,412, 115 basesExon 9: 37,734,399–37,735,442, 1,044 basesExon 10: 37,738,642–37,738,719, 78 basesExon 11: 37,740,895–37,741,032, 138 basesExon 12: 37,751,772–37,751,828, 57 basesExon 13: 37,754,877–37,754,984, 108 basesExon 14: 37,755,101–37,755,190, 90 basesExon 15: 37,755,550–37,755,659, 110 basesExon 16: 37,757,613–37,758,138, 526 basesExon 17: 37,759,154–37,759,264, 111 basesExon 18: 37,765,670–37,765,817, 148 basesExon 19: 37,768,074–37,768,176, 103 basesExon 20: 37,769,028–37,769,187, 160 basesExon 21: 37,769,262–37,769,375, 114 basesExon 22: 37,771,650–37,771,736, 87 basesExon 23: 37,772,601–37,772,764, 164 basesExon 24: 37,773,783–37,776,556, 2,774 bases15101520245′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 10.1 kb of the gene's 79.5 kb; 7,098 of those bases code for the protein.

    How a genome test reads TRIOBP

    65

    positions in TRIOBP where ClinVar classes a change as pathogenic or likely pathogenic

    6 of them (9.2%) fall in regions short reads find hard.

    • Low mappability (6 sites)Regions where 100 bp or 250 bp reads cannot be placed uniquely.

    A whole genome covers all 79.5 kb of TRIOBP, introns included, not only the 10.1 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). TRIOBP gene: TRIO and F-actin binding protein. Retrieved 16 October 2026, from https://dantelabs.com/genes/triobp

    Vancouver

    Dante Labs. TRIOBP gene: TRIO and F-actin binding protein [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/triobp

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