Traits

Traits linked to SCN10A

sodium voltage-gated channel alpha subunit 10

The Human Phenotype Ontology links 28 traits to SCN10A, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the cardiovascular system

Trait	How often it is seen
Redness of skin or mucous membrane	Very often (80–99%)
Complete right bundle branch block	Often (30–79%)
Fainting spell	Often (30–79%)
Heart stops beating	Often (30–79%)
ST segment elevation	Often (30–79%)
Elevated heart rate	Sometimes (5–29%)
First degree atrioventricular block	Sometimes (5–29%)
Inflammation of blood vessel	Sometimes (5–29%)
Paroxysmal ventricular tachycardia	Sometimes (5–29%)
Sick sinus syndrome	Sometimes (5–29%)
Supraventricular tachycardia	Sometimes (5–29%)
Ventricular fibrillation	Sometimes (5–29%)
Trifascicular block	Rarely (1–4%)
Ventricular arrhythmia	Rarely (1–4%)

Abnormality of the nervous system

Trait	How often it is seen
Dysesthesia	Always
Epilepsy	Very often (80–99%)
Peripheral neuropathy	Very often (80–99%)
Decreased sensation in extremities	Sometimes (5–29%)

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Blood cancer	Sometimes (5–29%)
Platelet abnormalities	Sometimes (5–29%)

Abnormality of limbs

Trait	How often it is seen
Decreased/absent ankle reflexes	Sometimes (5–29%)
Fluid accumulation in lower limbs	Sometimes (5–29%)

Constitutional symptom

Trait	How often it is seen
Erythromelalgia	Very often (80–99%)
Allodynia	Sometimes (5–29%)

Abnormality of the digestive system

Trait	How often it is seen
Constipation	Often (30–79%)

Abnormality of the immune system

Trait	How often it is seen
Recurrent respiratory infections	Sometimes (5–29%)

Abnormality of the integument

Trait	How often it is seen
Itching	Often (30–79%)

Laboratory abnormality

Trait	How often it is seen
Hypothermia	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to SCN10A and how often each is seen. Find out more at hpo.jax.org.

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test