Traits

Traits linked to PRKCG

protein kinase C gamma

The Human Phenotype Ontology links 27 traits to PRKCG, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Inability to coordinate movements when walking	Very often (80–99%)
Cerebellar vermis atrophy	Often (30–79%)
Limb ataxia	Often (30–79%)
Progressive cerebellar ataxia	Often (30–79%)
Cognitive impairment	Sometimes (5–29%)
Difficulty articulating speech	Sometimes (5–29%)
Jerking	Sometimes (5–29%)
Somatic sensory dysfunction	Sometimes (5–29%)
Tremor	Sometimes (5–29%)
Attention deficit	Not recorded
Degeneration of cerebellum	Not recorded
Depression	Not recorded
Focal dystonia	Not recorded
Impaired vibration sensation at ankles	Not recorded
Increased reflexes	Not recorded
Lack of coordination of movement	Not recorded
Memory impairment	Not recorded
Mental deterioration	Not recorded

Abnormality of the eye

Trait	How often it is seen
Gaze-evoked nystagmus	Sometimes (5–29%)
Saccadic smooth pursuit interruptions	Sometimes (5–29%)
Involuntary, rapid, rhythmic eye movements	Not recorded

Abnormality of limbs

Trait	How often it is seen
Abnormality of the Achilles tendon	Often (30–79%)
Hyporeflexia of lower limbs	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Generalized decreased muscle tone	Often (30–79%)
Rigidity	Sometimes (5–29%)

Abnormality of head or neck

Trait	How often it is seen
Involuntary facial quivering	Not recorded

Abnormality of the digestive system

Trait	How often it is seen
Poor swallowing	Not recorded

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to PRKCG and how often each is seen. Find out more at hpo.jax.org.

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