Traits

Traits linked to NOS3

nitric oxide synthase 3

The Human Phenotype Ontology links 23 traits to NOS3, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the cardiovascular system

Trait	How often it is seen
Anterior cerebral artery stenosis	Always
Ischemic stroke	Always
Middle cerebral artery stenosis	Always
Moyamoya phenomenon	Always
Narrowing of an artery	Always
Posterior cerebral artery stenosis	Always
Mini stroke	Often (30–79%)

Abnormality of the nervous system

Trait	How often it is seen
Delayed speech and language development	Always
Global developmental delay	Always
Intellectual disability	Always
Oromotor apraxia	Always
Weakness of one side of body	Always

Abnormality of the eye

Trait	How often it is seen
Close sighted	Always
Hemianopia	Always
High eye pressure	Always
Glaucoma	Often (30–79%)

Abnormality of head or neck

Trait	How often it is seen
Long philtrum	Often (30–79%)
Short columella	Often (30–79%)

Growth abnormality

Trait	How often it is seen
Prenatal growth deficiency	Often (30–79%)
Short stature	Often (30–79%)

Abnormality of limbs

Trait	How often it is seen
Prominent fingertip pads	Often (30–79%)

Abnormality of the genitourinary system

Trait	How often it is seen
Undescended testes	Always

Laboratory abnormality

Trait	How often it is seen
Low blood sugar in newborn	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to NOS3 and how often each is seen. Find out more at hpo.jax.org.

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