Traits

Traits linked to MANF

mesencephalic astrocyte derived neurotrophic factor

The Human Phenotype Ontology links 14 traits to MANF, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the endocrine system

Trait	How often it is seen
Decreased circulating follicle stimulating hormone concentration	Often (30–79%)
Decreased circulating luteinizing hormone level	Often (30–79%)
Decreased thyroid-stimulating hormone level	Often (30–79%)
Hypergonadotropic hypogonadism	Often (30–79%)
Hypopituitarism	Often (30–79%)
Reduced circulating growth hormone concentration	Often (30–79%)

Abnormality of head or neck

Trait	How often it is seen
Abnormally small head	Always

Abnormality of the ear

Trait	How often it is seen
Sensorineural hearing impairment	Always

Abnormality of the eye

Trait	How often it is seen
Severe near sightedness	Often (30–79%)

Abnormality of the integument

Trait	How often it is seen
Hair loss	Often (30–79%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Scoliosis	Often (30–79%)

Abnormality of the nervous system

Trait	How often it is seen
Global developmental delay	Always

Growth abnormality

Trait	How often it is seen
Short stature	Always

Laboratory abnormality

Trait	How often it is seen
Noninsulin-dependent diabetes	Always

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to MANF and how often each is seen. Find out more at hpo.jax.org.

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