Traits

Traits linked to KCNA4

potassium voltage-gated channel subfamily A member 4

The Human Phenotype Ontology links 16 traits to KCNA4, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Attention deficit	Always
Babinski sign	Always
Delayed motor skills	Always
Difficulty articulating speech	Always
Dystonia	Always
Intellectual disability	Always
Delayed speech and language development	Often (30–79%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Cogwheel rigidity	Always
Spastic walk	Always
Spasticity and rigidity of muscles	Not recorded

Growth abnormality

Trait	How often it is seen
Decreased body weight	Always
Growth delay	Always
Short stature	Always

Abnormality of the eye

Trait	How often it is seen
Clouding of the lens of the eye at birth	Always
Glaucoma	Sometimes (5–29%)

Abnormality of head or neck

Trait	How often it is seen
Abnormally small head	Always

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to KCNA4 and how often each is seen. Find out more at hpo.jax.org.

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