Traits

Traits linked to FECH

ferrochelatase

The Human Phenotype Ontology links 14 traits to FECH, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the digestive system

Trait	How often it is seen
Decreased liver function	Sometimes (5–29%)
Gallstones	Sometimes (5–29%)
Scar tissue replaces healthy tissue in the liver	Sometimes (5–29%)
Liver failure	Not recorded

Laboratory abnormality

Trait	How often it is seen
Abnormal circulating porphyrin concentration	Very often (80–99%)
Fluid retention	Sometimes (5–29%)
Increased plasma triglycerides	Not recorded
Low tissue ferrochelatase activity	Not recorded

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Microcytic anemia	Sometimes (5–29%)
Hemolytic anemia	Not recorded

Abnormality of the integument

Trait	How often it is seen
Itching	Very often (80–99%)
Photosensitive skin	Very often (80–99%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Redness of skin or mucous membrane	Very often (80–99%)

Abnormality of the immune system

Trait	How often it is seen
Eczema	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to FECH and how often each is seen. Find out more at hpo.jax.org.

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