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Gene

APH1B

aph-1B gamma-secretase subunit

Summary

Cytogenetic location
15q22.2
Coordinates
Chromosome 15: 63,277,605–63,309,126 (GRCh38)
Exons
6 exons across 31.5 kb
Protein
257 amino acids
Also known as
PSFL, APH-1B, DKFZp564D0372
MANE Select transcript
ENST00000261879.10NM_031301.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads APH1B yet. The test sequences your whole genome, so your data includes it all the same.

How APH1B is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 15, with a bracket where APH1B sits. APH1B and 9 genes near it on chromosome 15, from 62,793,366 to 63,793,365.Chromosome 1515q22.2p13p12p11.2p11.1q11.1q11.2q12q13.1q13.2q13.3q14q15.1q15.2q15.3q21.1q21.2q21.3q22.1q22.2q22.31q22.32q22.33q23q24.1q24.2q24.3q25.1q25.2q25.3q26.1q26.2q26.362.8 Mb63 Mb63.2 Mb63.4 Mb63.6 MbTLN2: 62,390,489–62,844,631, forward strandTLN2TPM1: 63,042,130–63,071,915, forward strandTPM1LACTB: 63,121,814–63,142,061, forward strandLACTBRPS27L: 63,125,859–63,158,021, reverse strandRPS27LRAB8B: 63,189,530–63,268,167, forward strandRAB8BAPH1B: 63,277,605–63,309,126, forward strandAPH1BCA12: 63,321,378–63,382,252, reverse strandCA12USP3: 63,504,501–63,594,640, forward strandUSP3FBXL22: 63,597,199–63,609,030, forward strandFBXL22HERC1: 63,608,618–63,833,997, reverse strandHERC1Diagram of APH1B: 6 exons on the forward strand of chromosome 15Exon 1: 63,277,605–63,277,736, 132 basesExon 2: 63,279,161–63,279,331, 171 basesExon 3: 63,286,558–63,286,628, 71 basesExon 4: 63,287,424–63,287,546, 123 basesExon 5: 63,302,345–63,302,472, 128 basesExon 6: 63,305,614–63,309,126, 3,513 bases1234565′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.1 kb of the gene's 31.5 kb; 774 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.

Cite this page

APA

Dante Labs. (n.d.). APH1B gene: aph-1B gamma-secretase subunit. Retrieved 17 October 2026, from https://dantelabs.com/genes/aph1b

Vancouver

Dante Labs. APH1B gene: aph-1B gamma-secretase subunit [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/aph1b

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