Traits

Traits linked to ADGRG6

adhesion G protein-coupled receptor G6

The Human Phenotype Ontology links 32 traits to ADGRG6, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the musculoskeletal system

Trait	How often it is seen
Arthrogryposis multiplex congenita	Always
Abnormality of the diaphragm	Sometimes (5–29%)
Ankylosis	Sometimes (5–29%)
Centrally nucleated skeletal muscle fibers	Sometimes (5–29%)
Elbow extension contracture	Sometimes (5–29%)
Flexed joint that cannot be straightened	Sometimes (5–29%)
Increased variability in muscle fiber diameter	Sometimes (5–29%)
Muscle fiber degeneration	Sometimes (5–29%)
Thoracic kyphoscoliosis	Sometimes (5–29%)
Congenital contracture	Not recorded
Muscle tissue disease	Not recorded

Abnormality of head or neck

Trait	How often it is seen
Little lower jaw	Often (30–79%)
Depressed nasal bridge	Sometimes (5–29%)
Nasal tip, upturned	Sometimes (5–29%)
Thin red part of the upper lip	Sometimes (5–29%)
Triangular face	Sometimes (5–29%)

Abnormality of limbs

Trait	How often it is seen
Club feet	Often (30–79%)
Inward turned thumb	Sometimes (5–29%)
Joint contracture of the hand	Sometimes (5–29%)
Ulnar deviation of the hand	Sometimes (5–29%)
Wrist flexion contracture	Sometimes (5–29%)

Abnormality of prenatal development or birth

Trait	How often it is seen
High levels of amniotic fluid	Often (30–79%)
Less than 10 fetal movements in 12 hours	Often (30–79%)
Absence of stomach bubble on fetal sonography	Sometimes (5–29%)
Short umbilical cord	Sometimes (5–29%)

Abnormality of the integument

Trait	How often it is seen
Antecubital pterygium	Sometimes (5–29%)
Axillary pterygium	Sometimes (5–29%)

Abnormality of the respiratory system

Trait	How often it is seen
Cardiorespiratory arrest	Sometimes (5–29%)
Poorly developed lungs	Sometimes (5–29%)

Abnormality of the ear

Trait	How often it is seen
Low-set ears	Often (30–79%)

Abnormality of the eye

Trait	How often it is seen
Wide-set eyes	Sometimes (5–29%)

Growth abnormality

Trait	How often it is seen
Prenatal growth deficiency	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to ADGRG6 and how often each is seen. Find out more at hpo.jax.org.

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