Traits

Traits linked to ADCY6

adenylate cyclase 6

The Human Phenotype Ontology links 18 traits to ADCY6, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the musculoskeletal system

Trait	How often it is seen
Distal arthrogryposis	Always
Distal muscle wasting	Always
Low muscle tone	Always
EMG abnormality	Very often (80–99%)
Limitation of joint mobility	Very often (80–99%)
Flexed joint that cannot be straightened	Not recorded

Abnormality of the nervous system

Trait	How often it is seen
Absent reflexes	Always
Decreased sensation in extremities	Always
Inability to move vocal cords	Always
Peripheral hypomyelination	Always
Diminished deep tendon reflex	Very often (80–99%)

Abnormality of limbs

Trait	How often it is seen
Hammertoe	Always
High-arched foot	Always

Abnormality of the digestive system

Trait	How often it is seen
Feeding difficulties	Always
Oral-pharyngeal dysphagia	Not recorded

Abnormality of head or neck

Trait	How often it is seen
Facial diplegia	Always

Abnormality of prenatal development or birth

Trait	How often it is seen
Less than 10 fetal movements in 12 hours	Always

Abnormality of the respiratory system

Trait	How often it is seen
Breathing difficulties	Very often (80–99%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to ADCY6 and how often each is seen. Find out more at hpo.jax.org.

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test