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Risk score · Cancer
Non-Hodgkin Lymphoma Polygenic Risk Score
Non-Hodgkin lymphoma is a cancer of the lymphatic system with many subtypes. Family history, autoimmune disease and HIV infection are among the factors that raise risk.
A risk score adds up many common variants, each with a small effect, into an estimate of genetic predisposition. It is not a diagnosis.
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Limitations
- Polygenic scores use common genetic variants, so they do not capture HIV infection or autoimmune disease, which raise risk.
References
- Cerhan JR, Slager SL, 2015. Familial predisposition and genetic risk factors for lymphoma
- Ansari N, Salesi M, 2024. The association between primary Sjogren's syndrome and non-Hodgkin's lymphoma: a systematic review and meta-analysis of cohort studies
- Murugan S, Chapanduka ZC, Rapiti N, 2026. From Divergent Pathogenesis to Precision Medicine: The Road to Targeted Therapy in HIV-Associated and HIV-Unrelated Diffuse Large B-Cell Lymphoma
Other cancer risk scores
- Basal Cell Carcinoma
- Bladder Cancer
- Chronic Lymphocytic Leukaemia (CLL)
- Colorectal Cancer
- Glioma
- Lung Cancer
- Melanoma
- Multiple Myeloma
- Ovarian Cancer
- Pancreatic Cancer
- Prostate Cancer
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