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Risk score · Cancer

Chronic Lymphocytic Leukaemia (CLL) Polygenic Risk Score

Chronic lymphocytic leukaemia (CLL) is a cancer of white blood cells and one of the main leukaemias in adults in Western countries. A family history of CLL is a strong risk factor.

A risk score adds up many common variants, each with a small effect, into an estimate of genetic predisposition. It is not a diagnosis.

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Limitations

  • The score does not include farming or pesticide exposure, which some studies associate with CLL.

References

  1. Caporaso N, Marti GE, Goldin L, 2004. Perspectives on familial chronic lymphocytic leukemia: genes and the environment
  2. Cerhan JR, Slager SL, 2015. Familial predisposition and genetic risk factors for lymphoma
  3. Sud A, Chattopadhyay S, Thomsen H, Sundquist K, Sundquist J, Houlston RS et al., 2019. Analysis of 153 115 patients with hematological malignancies refines the spectrum of familial risk

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