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Risk score · Cancer
Multiple Myeloma Polygenic Risk Score
Multiple myeloma is a common haematological cancer. It develops from precursor conditions such as MGUS and smouldering myeloma. Obesity, older age and family history are among the factors that raise risk.
A risk score adds up many common variants, each with a small effect, into an estimate of genetic predisposition. It is not a diagnosis.
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Limitations
- The score does not capture non-genetic factors such as obesity, low vitamin D or herbicide exposure, which studies link to multiple myeloma.
References
- Ma W, Zhao L, Zhou W, 2025. Risk factors for multiple myeloma and its precursor diseases
- Zanwar S, Kumar S, Rajkumar SV, 2026. Diagnosis, risk stratification and management of smouldering multiple myeloma
Other cancer risk scores
- Basal Cell Carcinoma
- Bladder Cancer
- Chronic Lymphocytic Leukaemia (CLL)
- Colorectal Cancer
- Glioma
- Lung Cancer
- Melanoma
- Non-Hodgkin Lymphoma
- Ovarian Cancer
- Pancreatic Cancer
- Prostate Cancer
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