{
  "url": "https://dantelabs.com/traits/renal-neoplasm",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "renal-neoplasm",
    "id": "HP:0009726",
    "name": "Kidney cancer",
    "label": "Renal neoplasm",
    "definition": "The presence of a neoplasm of the kidney.",
    "synonyms": [
      "Renal tumors",
      "Neoplasia of the kidneys",
      "Renal tumours"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-genitourinary-system",
        "name": "Abnormality of the genitourinary system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-genitourinary-system"
      },
      {
        "slug": "neoplasm",
        "name": "Abnormal tissue mass",
        "url": "https://dantelabs.com/traits/neoplasm"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-the-kidney",
        "name": "Abnormality of the kidney",
        "url": "https://dantelabs.com/traits/abnormality-of-the-kidney"
      },
      {
        "slug": "urinary-tract-neoplasm",
        "name": "Urinary tract neoplasm",
        "url": "https://dantelabs.com/traits/urinary-tract-neoplasm"
      }
    ],
    "narrower": [
      {
        "slug": "renal-cell-carcinoma",
        "name": "Cancer starting in small tubes in kidneys",
        "genes": 62,
        "url": "https://dantelabs.com/traits/renal-cell-carcinoma"
      },
      {
        "slug": "renal-hamartoma",
        "name": "Renal hamartoma",
        "genes": 2,
        "url": "https://dantelabs.com/traits/renal-hamartoma"
      },
      {
        "slug": "renal-cortical-adenoma",
        "name": "Renal cortical adenoma",
        "genes": 1,
        "url": "https://dantelabs.com/traits/renal-cortical-adenoma"
      },
      {
        "slug": "renal-transitional-cell-carcinoma",
        "name": "Renal transitional cell carcinoma",
        "genes": 1,
        "url": "https://dantelabs.com/traits/renal-transitional-cell-carcinoma"
      },
      {
        "slug": "rhabdoid-tumor-of-the-kidney",
        "name": "Rhabdoid tumor of the kidney",
        "genes": 1,
        "url": "https://dantelabs.com/traits/rhabdoid-tumor-of-the-kidney"
      },
      {
        "slug": "embryonal-renal-neoplasm",
        "name": "Embryonal renal neoplasm",
        "genes": 0,
        "url": "https://dantelabs.com/traits/embryonal-renal-neoplasm"
      }
    ],
    "genes": [
      {
        "slug": "lmna",
        "symbol": "LMNA",
        "hgnc": "HGNC:6636",
        "name": "lamin A/C",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lmna"
      },
      {
        "slug": "b3galt6",
        "symbol": "B3GALT6",
        "hgnc": "HGNC:17978",
        "name": "beta-1,3-galactosyltransferase 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/b3galt6"
      },
      {
        "slug": "epcam",
        "symbol": "EPCAM",
        "hgnc": "HGNC:11529",
        "name": "epithelial cell adhesion molecule",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/epcam"
      },
      {
        "slug": "kras",
        "symbol": "KRAS",
        "hgnc": "HGNC:6407",
        "name": "KRas proto-oncogene, GTPase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kras"
      },
      {
        "slug": "mlh1",
        "symbol": "MLH1",
        "hgnc": "HGNC:7127",
        "name": "mutL homolog 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mlh1"
      },
      {
        "slug": "msh2",
        "symbol": "MSH2",
        "hgnc": "HGNC:7325",
        "name": "mutS homolog 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/msh2"
      },
      {
        "slug": "msh6",
        "symbol": "MSH6",
        "hgnc": "HGNC:7329",
        "name": "mutS homolog 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/msh6"
      },
      {
        "slug": "pik3ca",
        "symbol": "PIK3CA",
        "hgnc": "HGNC:8975",
        "name": "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pik3ca"
      },
      {
        "slug": "pms1",
        "symbol": "PMS1",
        "hgnc": "HGNC:9121",
        "name": "PMS1 homolog 1, mismatch repair system component",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pms1"
      },
      {
        "slug": "pms2",
        "symbol": "PMS2",
        "hgnc": "HGNC:9122",
        "name": "PMS1 homolog 2, mismatch repair system component",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pms2"
      },
      {
        "slug": "tgfbr2",
        "symbol": "TGFBR2",
        "hgnc": "HGNC:11773",
        "name": "transforming growth factor beta receptor 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tgfbr2"
      },
      {
        "slug": "tsc1",
        "symbol": "TSC1",
        "hgnc": "HGNC:12362",
        "name": "TSC complex subunit 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tsc1"
      },
      {
        "slug": "tsc2",
        "symbol": "TSC2",
        "hgnc": "HGNC:12363",
        "name": "TSC complex subunit 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tsc2"
      },
      {
        "slug": "wrn",
        "symbol": "WRN",
        "hgnc": "HGNC:12791",
        "name": "WRN RecQ like helicase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wrn"
      },
      {
        "slug": "cdkn2a",
        "symbol": "CDKN2A",
        "hgnc": "HGNC:1787",
        "name": "cyclin dependent kinase inhibitor 2A",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdkn2a"
      },
      {
        "slug": "chek2",
        "symbol": "CHEK2",
        "hgnc": "HGNC:16627",
        "name": "checkpoint kinase 2",
        "frequency": "very-rare",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/chek2"
      },
      {
        "slug": "mdm2",
        "symbol": "MDM2",
        "hgnc": "HGNC:6973",
        "name": "MDM2 proto-oncogene",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mdm2"
      },
      {
        "slug": "tp53",
        "symbol": "TP53",
        "hgnc": "HGNC:11998",
        "name": "tumor protein p53",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tp53"
      },
      {
        "slug": "atm",
        "symbol": "ATM",
        "hgnc": "HGNC:795",
        "name": "ATM serine/threonine kinase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atm"
      },
      {
        "slug": "bmpr1a",
        "symbol": "BMPR1A",
        "hgnc": "HGNC:1076",
        "name": "bone morphogenetic protein receptor type 1A",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bmpr1a"
      },
      {
        "slug": "brca2",
        "symbol": "BRCA2",
        "hgnc": "HGNC:1101",
        "name": "BRCA2 DNA repair associated",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/brca2"
      },
      {
        "slug": "flcn",
        "symbol": "FLCN",
        "hgnc": "HGNC:27310",
        "name": "folliculin",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/flcn"
      },
      {
        "slug": "klln",
        "symbol": "KLLN",
        "hgnc": "HGNC:37212",
        "name": "killin, p53 regulated DNA replication inhibitor",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/klln"
      },
      {
        "slug": "mutyh",
        "symbol": "MUTYH",
        "hgnc": "HGNC:7527",
        "name": "mutY DNA glycosylase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mutyh"
      },
      {
        "slug": "npat",
        "symbol": "NPAT",
        "hgnc": "HGNC:7896",
        "name": "nuclear protein, coactivator of histone transcription",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/npat"
      },
      {
        "slug": "pold1",
        "symbol": "POLD1",
        "hgnc": "HGNC:9175",
        "name": "DNA polymerase delta 1, catalytic subunit",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pold1"
      },
      {
        "slug": "pole",
        "symbol": "POLE",
        "hgnc": "HGNC:9177",
        "name": "DNA polymerase epsilon, catalytic subunit",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pole"
      },
      {
        "slug": "rps20",
        "symbol": "RPS20",
        "hgnc": "HGNC:10405",
        "name": "ribosomal protein S20",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rps20"
      },
      {
        "slug": "sema4a",
        "symbol": "SEMA4A",
        "hgnc": "HGNC:10729",
        "name": "semaphorin 4A",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sema4a"
      }
    ]
  }
}