Traits

Traits linked to SEMA3D

semaphorin 3D

The Human Phenotype Ontology links 19 traits to SEMA3D, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the digestive system

Trait	How often it is seen
Abdominal pain	Very often (80–99%)
Constipation	Very often (80–99%)
Enlarged colon lacking nerve cells	Very often (80–99%)
Functional abnormality of the gastrointestinal tract	Very often (80–99%)
Intestinal obstruction	Very often (80–99%)
Nausea and vomiting	Very often (80–99%)
Abdominal bloating	Often (30–79%)
Bilious emesis	Often (30–79%)
Feeding difficulties	Often (30–79%)
Colon perforation	Sometimes (5–29%)
Diarrhea	Sometimes (5–29%)
Enterocolitis	Sometimes (5–29%)

Growth abnormality

Trait	How often it is seen
Weight loss	Often (30–79%)
Faltering weight in infancy	Sometimes (5–29%)
Growth delay	Sometimes (5–29%)
Short stature	Sometimes (5–29%)

Abnormality of prenatal development or birth

Trait	How often it is seen
Delayed passage of meconium	Often (30–79%)
High levels of amniotic fluid	Sometimes (5–29%)

Abnormality of the immune system

Trait	How often it is seen
Infection in blood stream	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to SEMA3D and how often each is seen. Find out more at hpo.jax.org.

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