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Gene

S1PR2

sphingosine-1-phosphate receptor 2

Summary

Cytogenetic location
19p13.2
Coordinates
Chromosome 19: 10,221,433–10,231,331 (GRCh38)
Exons
2 exons across 9.9 kb
Protein
353 amino acids
Also known as
Gpcr13, H218, AGR16
Previous symbols
EDG5, DFNB68
MANE Select transcript
ENST00000646641.1NM_004230.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Hearing Loss and Deafness

      • Nonsyndromic Genetic Hearing Loss

        One of 97 genes linked to it

        Inherited hearing loss without other medical features, including the common recessive forms caused by GJB2, OTOF, SLC26A4, STRC and many other genes, as well as dominant, X-linked and mitochondrial forms.

        • ClinGen rates the link strong
        • 3 GenCC submitters rate it definitive or strong
        What knowing changes

        Knowing the genetic cause can guide hearing support and cochlear implant decisions, gene-therapy trial eligibility (for example OTOF) and family counselling.

    How S1PR2 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Stretches short reads find hard
    Chromosome 19, with a bracket where S1PR2 sits. S1PR2 and 37 genes near it on chromosome 19, from 9,726,382 to 10,726,381.Chromosome 1919p13.2p13.3p13.2p13.13p13.12p13.11p12p11q11q12q13.11q13.12q13.13q13.2q13.31q13.32q13.33q13.41q13.42q13.439.8 Mb10 Mb10.2 Mb10.4 Mb10.6 MbZNF846: 9,749,546–9,793,180, reverse strandZNF846FBXL12: 9,810,267–9,827,816, reverse strandFBXL12UBL5: 9,827,887–9,830,369, forward strandUBL5PIN1: 9,835,257–9,849,690, forward strandPIN1OLFM2: 9,853,717–9,936,559, reverse strandOLFM2COL5A3: 9,959,561–10,010,511, reverse strandCOL5A3RDH8: 10,013,249–10,022,279, forward strandRDH8SHFL: 10,086,017–10,093,252, forward strandANGPTL6: 10,092,335–10,106,612, reverse strandPPAN-P2RY11: 10,106,223–10,114,780, forward strandPPAN-P2RY11PPAN: 10,106,300–10,112,813, forward strandP2RY11: 10,111,689–10,118,085, forward strandP2RY11EIF3G: 10,115,010–10,119,951, reverse strandEIF3GDNMT1: 10,133,342–10,231,286, reverse strandDNMT1S1PR2: 10,221,433–10,231,331, reverse strandS1PR2MRPL4: 10,251,901–10,260,060, forward strandMRPL4ICAM1: 10,271,093–10,286,617, forward strandICAM1ICAM4: 10,286,946–10,288,522, forward strandICAM4ICAM5: 10,289,940–10,296,778, forward strandICAM5ZGLP1: 10,304,803–10,309,880, reverse strandFDX2-ZGLP1: 10,305,427–10,316,009, reverse strandFDX2: 10,309,898–10,316,026, reverse strand: 10,315,471–10,320,678, reverse strandRAVER1: 10,316,212–10,333,548, reverse strandICAM3: 10,333,776–10,339,847, reverse strandTYK2: 10,350,528–10,380,608, reverse strandTYK2CDC37: 10,391,090–10,420,224, reverse strandCDC37PDE4A: 10,416,773–10,469,816, forward strandPDE4AKEAP1: 10,484,512–10,503,558, reverse strandKEAP1S1PR5: 10,512,742–10,517,981, reverse strandS1PR5ATG4D: 10,543,533–10,553,556, forward strandATG4DKRI1: 10,553,085–10,566,031, reverse strandKRI1CDKN2D: 10,566,460–10,569,059, reverse strandCDKN2DAP1M2: 10,569,431–10,587,317, reverse strandAP1M2SLC44A2: 10,602,457–10,644,559, forward strandSLC44A2ILF3: 10,654,261–10,692,415, forward strandILF3QTRT1: 10,701,430–10,713,747, forward strandQTRT1DNM2: 10,717,967–10,834,209, forward strandDNM2Diagram of S1PR2: 2 exons on the reverse strand of chromosome 19Exon 2: 10,221,433–10,224,947, 3,515 basesExon 1: 10,231,204–10,231,331, 128 bases215′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 3.6 kb of the gene's 9.9 kb; 1,062 of those bases code for the protein.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). S1PR2 gene: sphingosine-1-phosphate receptor 2. Retrieved 16 October 2026, from https://dantelabs.com/genes/s1pr2

    Vancouver

    Dante Labs. S1PR2 gene: sphingosine-1-phosphate receptor 2 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/s1pr2

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