Traits

Traits linked to PRDM10

PR/SET domain 10

The Human Phenotype Ontology links 23 traits to PRDM10, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the integument

Trait	How often it is seen
Fibrofolliculoma	Very often (80–99%)
Skin tags	Very often (80–99%)
Perifollicular fibroma	Often (30–79%)
Collagenoma	Sometimes (5–29%)
Cutaneous melanoma	Sometimes (5–29%)
Epidermoid cyst	Sometimes (5–29%)
Trichodiscoma	Sometimes (5–29%)

Abnormality of the endocrine system

Trait	How often it is seen
Medullary thyroid carcinoma	Sometimes (5–29%)
Parathyroid adenoma	Sometimes (5–29%)
Thyroid cyst	Sometimes (5–29%)
Thyroid nodule	Sometimes (5–29%)

Abnormality of the respiratory system

Trait	How often it is seen
Multiple pulmonary cysts	Often (30–79%)
Repeated pneumothoraces	Often (30–79%)
Spontaneous collapsed lung	Often (30–79%)
Collapsed lung	Sometimes (5–29%)

Abnormality of the genitourinary system

Trait	How often it is seen
Clear cell renal cell carcinoma	Often (30–79%)
Cancer starting in small tubes in kidneys	Sometimes (5–29%)
Cystic kidney disease	Sometimes (5–29%)

Abnormal tissue mass

Trait	How often it is seen
Abnormal tissue mass	Sometimes (5–29%)
Angiofibromas	Sometimes (5–29%)

Abnormality of head or neck

Trait	How often it is seen
Oral mucosal papule	Sometimes (5–29%)
Salivary gland oncocytoma	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Multiple fatty lumps	Always

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to PRDM10 and how often each is seen. Find out more at hpo.jax.org.

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