Skip to content
Use your HSA or FSA funds

Gene

KLB

klotho beta

Summary

Cytogenetic location
4p14
Coordinates
Chromosome 4: 39,406,930–39,451,533 (GRCh38)
Exons
5 exons across 44.6 kb
Protein
1,044 amino acids
MANE Select transcript
ENST00000257408.5NM_175737.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Hypogonadotropic Hypogonadism

    • Abnormal ovarian or testicular function due to insufficient hormonal stimulation from the hypothalamic-pituitary axis.

      • 1 GenCC submitter rates it definitive or strong

How KLB is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 4, with a bracket where KLB sits. KLB and 11 genes near it on chromosome 4, from 38,929,232 to 39,929,231.Chromosome 44p14p16.3p16.2p16.1p15.33p15.32p15.31p15.2p15.1p14p13p12p11q11q12q13.1q13.2q13.3q21.1q21.21q21.22q21.23q21.3q22.1q22.2q22.3q23q24q25q26q27q28.1q28.2q28.3q31.1q31.21q31.22q31.23q31.3q32.1q32.2q32.3q33q34.1q34.2q34.3q35.1q35.239 Mb39.2 Mb39.4 Mb39.6 Mb39.8 MbFAM114A1: 38,867,677–38,945,740, forward strandFAM114A1TMEM156: 38,965,999–39,032,922, reverse strandTMEM156KLHL5: 39,044,613–39,126,857, forward strandKLHL5WDR19: 39,182,463–39,285,810, forward strandWDR19RFC1: 39,287,455–39,366,400, reverse strandRFC1KLB: 39,406,930–39,451,533, forward strandKLBRPL9: 39,450,679–39,472,424, reverse strandRPL9LIAS: 39,459,004–39,485,109, forward strandLIASUGDH: 39,498,755–39,528,311, reverse strandUGDHSMIM14: 39,546,336–39,639,092, reverse strandSMIM14UBE2K: 39,697,879–39,782,792, forward strandUBE2KPDS5A: 39,822,863–39,977,993, reverse strandPDS5ADiagram of KLB: 5 exons on the forward strand of chromosome 4Exon 1: 39,406,930–39,407,774, 845 basesExon 2: 39,434,210–39,434,720, 511 basesExon 3: 39,437,727–39,437,995, 269 basesExon 4: 39,446,332–39,447,475, 1,144 basesExon 5: 39,448,301–39,451,533, 3,233 bases123455′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 6 kb of the gene's 44.6 kb; 3,135 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). KLB gene: klotho beta. Retrieved 17 October 2026, from https://dantelabs.com/genes/klb

Vancouver

Dante Labs. KLB gene: klotho beta [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/klb

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test