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Traits

Traits linked to KL

klotho

The Human Phenotype Ontology links 12 traits to KL, by body system: features seen in people with one of the gene's rare conditions.

Laboratory abnormality

TraitHow often it is seen
Elevated circulating calcitriol concentrationAlways
Elevated circulating parathyroid hormone levelAlways
High blood calcium levelsAlways
High blood phosphate levelsAlways

Abnormality of limbs

TraitHow often it is seen
Achilles tendon calcificationAlways
Metacarpal periosteal thickeningAlways

Abnormality of the musculoskeletal system

TraitHow often it is seen
Abnormal deposits of calcium in the brainAlways
OsteopeniaAlways

Abnormality of head or neck

TraitHow often it is seen
Calvarial osteosclerosisAlways

Abnormality of the endocrine system

TraitHow often it is seen
Enlarged parathyroid glandsAlways

Abnormality of the nervous system

TraitHow often it is seen
HeadacheAlways

Constitutional symptom

TraitHow often it is seen
FatigueAlways

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to KL and how often each is seen. Find out more at hpo.jax.org.

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