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Gene

KCNK18

potassium two pore domain channel subfamily K member 18

Summary

Cytogenetic location
10q25.3
Coordinates
Chromosome 10: 117,197,489–117,210,299 (GRCh38)
Exons
3 exons across 12.8 kb
Protein
384 amino acids
Also known as
K2p18.1, TRESK-2, TRESK2, TRESK, TRIK
MANE Select transcript
ENST00000334549.1NM_181840.1
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads KCNK18 yet. The test sequences your whole genome, so your data includes it all the same.

How KCNK18 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 10, with a bracket where KCNK18 sits. KCNK18 and 7 genes near it on chromosome 10, from 116,703,894 to 117,703,893.Chromosome 1010q25.3p15.3p15.2p15.1p14p13p12.33p12.32p12.31p12.2p12.1p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.31q23.32q23.33q24.1q24.2q24.31q24.32q24.33q25.1q25.2q25.3q26.11q26.12q26.13q26.2q26.3116.8 Mb117 Mb117.2 Mb117.4 Mb117.6 MbHSPA12A: 116,671,192–116,850,251, reverse strandHSPA12AENO4: 116,849,481–116,911,788, forward strandENO4SHTN1: 116,881,477–117,126,586, reverse strandSHTN1VAX1: 117,128,521–117,138,629, reverse strandVAX1KCNK18: 117,197,489–117,210,299, forward strandKCNK18SLC18A2: 117,240,830–117,279,431, forward strandSLC18A2PDZD8: 117,277,274–117,376,020, reverse strandPDZD8EMX2: 117,542,445–117,549,546, forward strandEMX2Diagram of KCNK18: 3 exons on the forward strand of chromosome 10Exon 3: 2 known disease-causing sitesExon 1: 117,197,489–117,197,711, 223 basesExon 2: 117,201,159–117,201,287, 129 basesExon 3: 117,209,497–117,210,299, 803 bases1235′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.2 kb of the gene's 12.8 kb; 1,155 of those bases code for the protein.

How a genome test reads KCNK18

2

positions in KCNK18 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 12.8 kb of KCNK18, introns included, not only the 1.2 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). KCNK18 gene: potassium two pore domain channel subfamily K member 18. Retrieved 17 October 2026, from https://dantelabs.com/genes/kcnk18

Vancouver

Dante Labs. KCNK18 gene: potassium two pore domain channel subfamily K member 18 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/kcnk18

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