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Gene

IKZF5

IKAROS family zinc finger 5

Summary

Cytogenetic location
10q26.13
Coordinates
Chromosome 10: 122,990,807–123,008,795 (GRCh38)
Exons
5 exons across 18 kb
Protein
419 amino acids
Also known as
Pegasus, FLJ22973
Previous symbols
ZNFN1A5
MANE Select transcript
ENST00000368886.10NM_001372123.1
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Inherited Thrombocytopenias

    • Inherited Thrombocytopenia

      A group of conditions causing a lifelong low platelet count, linked to genes such as MYH9, ANKRD26, ETV6, WAS, MPL, RBM8A, GATA1 and MECOM, and inherited in dominant, recessive or X-linked patterns.

      • ClinGen rates the link moderate
      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      A genetic diagnosis avoids misdiagnosis as immune thrombocytopenia, with unnecessary steroids or spleen removal, and guides monitoring for related kidney, hearing or blood problems.

How IKZF5 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 10, with a bracket where IKZF5 sits. IKZF5 and 14 genes near it on chromosome 10, from 122,499,801 to 123,499,800.Chromosome 1010q26.13p15.3p15.2p15.1p14p13p12.33p12.32p12.31p12.2p12.1p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.31q23.32q23.33q24.1q24.2q24.31q24.32q24.33q25.1q25.2q25.3q26.11q26.12q26.13q26.2q26.3122.6 Mb122.8 Mb123 Mb123.2 Mb123.4 MbHTRA1: 122,458,551–122,516,001, forward strandHTRA1DMBT1: 122,560,641–122,643,740, forward strandDMBT1SPADH: 122,672,850–122,679,494, forward strandSPADHC10orf120: 122,697,709–122,699,846, reverse strandC10orf120CUZD1: 122,832,158–122,846,175, reverse strandCUZD1: 122,832,167–122,879,583, reverse strandFAM24B: 122,849,078–122,879,641, reverse strandFAM24BFAM24A: 122,910,604–122,913,111, forward strandFAM24AC10orf88: 122,930,901–122,954,337, reverse strandC10orf88PSTK: 122,954,381–122,997,513, forward strandPSTKIKZF5: 122,990,807–123,008,795, reverse strandIKZF5ACADSB: 123,008,972–123,058,300, forward strandACADSBHMX3: 123,135,957–123,139,423, forward strandHMX3HMX2: 123,142,401–123,150,672, forward strandHMX2BUB3: 123,154,365–123,313,144, forward strandBUB3Diagram of IKZF5: 5 exons on the reverse strand of chromosome 10Exon 5: 1 known disease-causing siteExon 4: 1 known disease-causing siteExon 5: 122,990,807–122,994,723, 3,917 basesExon 4: 122,995,994–122,996,176, 183 basesExon 3: 122,998,493–122,998,671, 179 basesExon 2: 123,007,026–123,007,176, 151 basesExon 1: 123,008,694–123,008,795, 102 bases543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.5 kb of the gene's 18 kb; 1,260 of those bases code for the protein.

How a genome test reads IKZF5

2

positions in IKZF5 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 18 kb of IKZF5, introns included, not only the 4.5 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). IKZF5 gene: IKAROS family zinc finger 5. Retrieved 16 October 2026, from https://dantelabs.com/genes/ikzf5

Vancouver

Dante Labs. IKZF5 gene: IKAROS family zinc finger 5 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/ikzf5

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