Traits

Traits linked to IKBKB

inhibitor of nuclear factor kappa B kinase subunit beta

The Human Phenotype Ontology links 19 traits to IKBKB, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the immune system

Trait	How often it is seen
Recurrent infections	Always
Recurrent respiratory infections	Often (30–79%)
Skin abscess	Often (30–79%)
Acne inversa	Sometimes (5–29%)
Recurrent mucocutaneous candidiasis	Sometimes (5–29%)
Decreased immune function	Not recorded

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Decreased memory B cell proportion	Always
Decreased total CD4+ T cell proportion	Always
Decreased total CD8+ T cell proportion	Always
High blood monocyte number	Often (30–79%)
Reduced total natural killer cell count	Often (30–79%)

Abnormal cellular phenotype

Trait	How often it is seen
Decreased circulating antibody level	Always
Agammaglobulinemia	Often (30–79%)
Decreased mitogen-induced T-cell proliferation	Often (30–79%)

Abnormality of head or neck

Trait	How often it is seen
Chronic oral thrush	Always
Recurrent sinus disease	Often (30–79%)

Abnormality of the digestive system

Trait	How often it is seen
Chronic diarrhea	Not recorded

Abnormality of the ear

Trait	How often it is seen
Recurrent middle ear infection	Often (30–79%)

Growth abnormality

Trait	How often it is seen
Faltering weight	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to IKBKB and how often each is seen. Find out more at hpo.jax.org.

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