Traits

Traits linked to DLX5

distal-less homeobox 5

The Human Phenotype Ontology links 24 traits to DLX5, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of limbs

Trait	How often it is seen
Split foot	Always
Split hand	Always
Oligodactyly	Very often (80–99%)
Absent fingers	Often (30–79%)
Finger syndactyly	Often (30–79%)
Hand monodactyly	Often (30–79%)
Missing toes	Often (30–79%)
Tapered finger	Often (30–79%)
Webbed fingers or toes	Often (30–79%)
Absent hand	Sometimes (5–29%)
Broad big toe	Not recorded
Cleft hand	Not recorded
Curvature of digit	Not recorded
Finger-like thumb	Not recorded

Abnormality of the ear

Trait	How often it is seen
Sensorineural hearing impairment	Always
Abnormally shaped ears	Often (30–79%)
Hearing impairment	Often (30–79%)

Abnormality of head or neck

Trait	How often it is seen
Cleft palate	Often (30–79%)
Frontal bossing	Often (30–79%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Abnormal cardiovascular system morphology	Sometimes (5–29%)

Abnormality of the eye

Trait	How often it is seen
Absent iris	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Scoliosis	Often (30–79%)

Abnormality of the nervous system

Trait	How often it is seen
Intellectual disability	Often (30–79%)

Growth abnormality

Trait	How often it is seen
Severe short stature	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to DLX5 and how often each is seen. Find out more at hpo.jax.org.

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