Traits

Traits linked to AXIN2

axin 2

The Human Phenotype Ontology links 20 traits to AXIN2, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the digestive system

Trait	How often it is seen
Adenomatous colonic polyposis	Often (30–79%)
Colorectal polyposis	Often (30–79%)
Colon cancer	Sometimes (5–29%)
Fundic gland polyposis	Sometimes (5–29%)
Rectal tumor	Sometimes (5–29%)
Hereditary nonpolyposis colorectal carcinoma	Not recorded
Stomach tumor	Not recorded

Abnormality of head or neck

Trait	How often it is seen
Failure of development of more than six teeth	Always
Absent eyebrow	Often (30–79%)
Sparse scalp hair	Often (30–79%)
Short eyelashes	Sometimes (5–29%)

Abnormality of the integument

Trait	How often it is seen
Limited armpit hair	Sometimes (5–29%)
Sparse body hair	Sometimes (5–29%)
Ectodermal dysplasia	Not recorded
Sparse hair	Not recorded

Abnormality of the genitourinary system

Trait	How often it is seen
Cancer starting in small tubes in kidneys	Not recorded
Transitional cell carcinoma of the bladder	Not recorded
Uterine leiomyosarcoma	Not recorded

Abnormality of the breast

Trait	How often it is seen
Breast cancer	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Abnormal odontoid tissue morphology	Not recorded

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to AXIN2 and how often each is seen. Find out more at hpo.jax.org.

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