Traits

Traits linked to ADCY3

adenylate cyclase 3

The Human Phenotype Ontology links 10 traits to ADCY3, by body system: features seen in people with one of the gene's rare conditions.

Laboratory abnormality

Trait	How often it is seen
Hyperinsulinemia	Often (30–79%)
Increased plasma triglycerides	Often (30–79%)
Body fails to respond to insulin	Sometimes (5–29%)
Elevated lipids in blood	Not recorded

Abnormality of head or neck

Trait	How often it is seen
Hyposmia	Often (30–79%)
Lost smell	Often (30–79%)

Abnormality of the nervous system

Trait	How often it is seen
Increased appetite	Always
Intellectual disability	Often (30–79%)

Abnormality of the endocrine system

Trait	How often it is seen
Increased serum leptin	Always

Growth abnormality

Trait	How often it is seen
Obesity	Always

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to ADCY3 and how often each is seen. Find out more at hpo.jax.org.

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