{
  "url": "https://dantelabs.com/traits/torsade-de-pointes",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "torsade-de-pointes",
    "id": "HP:0001664",
    "name": "Torsade de pointes",
    "definition": "A type of ventricular tachycardia characterized by polymorphioc QRS complexes that change in amplitue and cycle length, and thus have the appearance of oscillating around the baseline in the EKG.",
    "synonyms": [
      "Torsades de pointes"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-cardiovascular-system",
        "name": "Abnormality of the cardiovascular system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-cardiovascular-system"
      }
    ],
    "broader": [
      {
        "slug": "ventricular-arrhythmia",
        "name": "Ventricular arrhythmia",
        "url": "https://dantelabs.com/traits/ventricular-arrhythmia"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "hcn4",
        "symbol": "HCN4",
        "hgnc": "HGNC:16882",
        "name": "hyperpolarization activated cyclic nucleotide gated potassium channel 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hcn4"
      },
      {
        "slug": "scn5a",
        "symbol": "SCN5A",
        "hgnc": "HGNC:10593",
        "name": "sodium voltage-gated channel alpha subunit 5",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scn5a"
      },
      {
        "slug": "kcne1",
        "symbol": "KCNE1",
        "hgnc": "HGNC:6240",
        "name": "potassium voltage-gated channel subfamily E regulatory subunit 1",
        "frequency": "frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/kcne1"
      },
      {
        "slug": "kcne2",
        "symbol": "KCNE2",
        "hgnc": "HGNC:6242",
        "name": "potassium voltage-gated channel subfamily E regulatory subunit 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcne2"
      },
      {
        "slug": "kcnq1",
        "symbol": "KCNQ1",
        "hgnc": "HGNC:6294",
        "name": "potassium voltage-gated channel subfamily Q member 1",
        "frequency": "frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/kcnq1"
      },
      {
        "slug": "kcnj2",
        "symbol": "KCNJ2",
        "hgnc": "HGNC:6263",
        "name": "potassium inwardly rectifying channel subfamily J member 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnj2"
      },
      {
        "slug": "kcnj5",
        "symbol": "KCNJ5",
        "hgnc": "HGNC:6266",
        "name": "potassium inwardly rectifying channel subfamily J member 5",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/kcnj5"
      },
      {
        "slug": "tango2",
        "symbol": "TANGO2",
        "hgnc": "HGNC:25439",
        "name": "transport and golgi organization 2 homolog",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tango2"
      },
      {
        "slug": "ryr2",
        "symbol": "RYR2",
        "hgnc": "HGNC:10484",
        "name": "ryanodine receptor 2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ryr2"
      },
      {
        "slug": "alg10b",
        "symbol": "ALG10B",
        "hgnc": "HGNC:31088",
        "name": "ALG10 alpha-1,2-glucosyltransferase B",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alg10b"
      },
      {
        "slug": "kcnh2",
        "symbol": "KCNH2",
        "hgnc": "HGNC:6251",
        "name": "potassium voltage-gated channel subfamily H member 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnh2"
      },
      {
        "slug": "naa10",
        "symbol": "NAA10",
        "hgnc": "HGNC:18704",
        "name": "N-alpha-acetyltransferase 10, NatA catalytic subunit",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/naa10"
      },
      {
        "slug": "snta1",
        "symbol": "SNTA1",
        "hgnc": "HGNC:11167",
        "name": "syntrophin alpha 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/snta1"
      }
    ]
  }
}