{
  "url": "https://dantelabs.com/traits/subcutaneous-hemorrhage",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "subcutaneous-hemorrhage",
    "id": "HP:0001933",
    "name": "Bleeding below the skin",
    "label": "Subcutaneous hemorrhage",
    "definition": "This term refers to an abnormally increased susceptibility to bruising (purpura, petechiae, or ecchymoses).",
    "synonyms": [
      "Subcutaneous haemorrhage"
    ],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      },
      {
        "slug": "abnormality-of-the-cardiovascular-system",
        "name": "Abnormality of the cardiovascular system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-cardiovascular-system"
      },
      {
        "slug": "abnormality-of-the-integument",
        "name": "Abnormality of the integument",
        "url": "https://dantelabs.com/traits/abnormality-of-the-integument"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-bleeding",
        "name": "Bleeding tendency",
        "url": "https://dantelabs.com/traits/abnormal-bleeding"
      },
      {
        "slug": "vascular-skin-abnormality",
        "name": "Vascular skin abnormality",
        "url": "https://dantelabs.com/traits/vascular-skin-abnormality"
      }
    ],
    "narrower": [
      {
        "slug": "bruising-susceptibility",
        "name": "Bruising susceptibility",
        "genes": 190,
        "url": "https://dantelabs.com/traits/bruising-susceptibility"
      },
      {
        "slug": "purpura",
        "name": "Blood spots",
        "genes": 81,
        "url": "https://dantelabs.com/traits/purpura"
      },
      {
        "slug": "spontaneous-hematomas",
        "name": "Spontaneous hematomas",
        "genes": 19,
        "url": "https://dantelabs.com/traits/spontaneous-hematomas"
      }
    ],
    "genes": [
      {
        "slug": "ephb2",
        "symbol": "EPHB2",
        "hgnc": "HGNC:3393",
        "name": "EPH receptor B2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ephb2"
      },
      {
        "slug": "adamts2",
        "symbol": "ADAMTS2",
        "hgnc": "HGNC:218",
        "name": "ADAM metallopeptidase with thrombospondin type 1 motif 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/adamts2"
      },
      {
        "slug": "adamtsl2",
        "symbol": "ADAMTSL2",
        "hgnc": "HGNC:14631",
        "name": "ADAMTS like 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/adamtsl2"
      },
      {
        "slug": "arl6ip6",
        "symbol": "ARL6IP6",
        "hgnc": "HGNC:24048",
        "name": "ARF like GTPase 6 interacting protein 6",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/arl6ip6"
      },
      {
        "slug": "chst14",
        "symbol": "CHST14",
        "hgnc": "HGNC:24464",
        "name": "carbohydrate sulfotransferase 14",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chst14"
      },
      {
        "slug": "dse",
        "symbol": "DSE",
        "hgnc": "HGNC:21144",
        "name": "dermatan sulfate epimerase",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dse"
      },
      {
        "slug": "gna11",
        "symbol": "GNA11",
        "hgnc": "HGNC:4379",
        "name": "G protein subunit alpha 11",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gna11"
      },
      {
        "slug": "slc35a1",
        "symbol": "SLC35A1",
        "hgnc": "HGNC:11021",
        "name": "solute carrier family 35 member A1",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/slc35a1"
      },
      {
        "slug": "f13a1",
        "symbol": "F13A1",
        "hgnc": "HGNC:3531",
        "name": "coagulation factor XIII A chain",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/f13a1"
      },
      {
        "slug": "f13b",
        "symbol": "F13B",
        "hgnc": "HGNC:3534",
        "name": "coagulation factor XIII B chain",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/f13b"
      },
      {
        "slug": "f8",
        "symbol": "F8",
        "hgnc": "HGNC:3546",
        "name": "coagulation factor VIII",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/f8"
      },
      {
        "slug": "pros1",
        "symbol": "PROS1",
        "hgnc": "HGNC:9456",
        "name": "protein S",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pros1"
      },
      {
        "slug": "pten",
        "symbol": "PTEN",
        "hgnc": "HGNC:9588",
        "name": "phosphatase and tensin homolog",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pten"
      },
      {
        "slug": "serpine1",
        "symbol": "SERPINE1",
        "hgnc": "HGNC:8583",
        "name": "serpin family E member 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/serpine1"
      },
      {
        "slug": "cbs",
        "symbol": "CBS",
        "hgnc": "HGNC:1550",
        "name": "cystathionine beta-synthase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cbs"
      }
    ]
  }
}