{
  "url": "https://dantelabs.com/traits/irregularly-shaped-sperm-tail",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "irregularly-shaped-sperm-tail",
    "id": "HP:0033393",
    "name": "Irregularly shaped sperm tail",
    "definition": "Irregular or changing caliber (diameter) along the tail of the sperm.",
    "synonyms": [
      "Sperm flagella with irregular caliber",
      "Sperm flagella with irregular calibre"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-genitourinary-system",
        "name": "Abnormality of the genitourinary system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-genitourinary-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-sperm-tail-morphology",
        "name": "Abnormal sperm tail morphology",
        "url": "https://dantelabs.com/traits/abnormal-sperm-tail-morphology"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "brwd1",
        "symbol": "BRWD1",
        "hgnc": "HGNC:12760",
        "name": "bromodomain and WD repeat domain containing 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/brwd1"
      },
      {
        "slug": "ccin",
        "symbol": "CCIN",
        "hgnc": "HGNC:1568",
        "name": "calicin",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccin"
      },
      {
        "slug": "cfap206",
        "symbol": "CFAP206",
        "hgnc": "HGNC:21405",
        "name": "cilia and flagella associated protein 206",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfap206"
      },
      {
        "slug": "cfap251",
        "symbol": "CFAP251",
        "hgnc": "HGNC:28506",
        "name": "cilia and flagella associated protein 251",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfap251"
      },
      {
        "slug": "cfap47",
        "symbol": "CFAP47",
        "hgnc": "HGNC:26708",
        "name": "cilia and flagella associated protein 47",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfap47"
      },
      {
        "slug": "cfap54",
        "symbol": "CFAP54",
        "hgnc": "HGNC:26456",
        "name": "cilia and flagella associated protein 54",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfap54"
      },
      {
        "slug": "cfap57",
        "symbol": "CFAP57",
        "hgnc": "HGNC:26485",
        "name": "cilia and flagella associated protein 57",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfap57"
      },
      {
        "slug": "cfap61",
        "symbol": "CFAP61",
        "hgnc": "HGNC:15872",
        "name": "cilia and flagella associated protein 61",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfap61"
      },
      {
        "slug": "cfap91",
        "symbol": "CFAP91",
        "hgnc": "HGNC:24010",
        "name": "cilia and flagella associated protein 91",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cfap91"
      },
      {
        "slug": "dnah1",
        "symbol": "DNAH1",
        "hgnc": "HGNC:2940",
        "name": "dynein axonemal heavy chain 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnah1"
      },
      {
        "slug": "dnah10",
        "symbol": "DNAH10",
        "hgnc": "HGNC:2941",
        "name": "dynein axonemal heavy chain 10",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnah10"
      },
      {
        "slug": "dnah12",
        "symbol": "DNAH12",
        "hgnc": "HGNC:2943",
        "name": "dynein axonemal heavy chain 12",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnah12"
      },
      {
        "slug": "dnah8",
        "symbol": "DNAH8",
        "hgnc": "HGNC:2952",
        "name": "dynein axonemal heavy chain 8",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnah8"
      },
      {
        "slug": "dnhd1",
        "symbol": "DNHD1",
        "hgnc": "HGNC:26532",
        "name": "dynein heavy chain domain 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dnhd1"
      },
      {
        "slug": "fsip2",
        "symbol": "FSIP2",
        "hgnc": "HGNC:21675",
        "name": "fibrous sheath interacting protein 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fsip2"
      },
      {
        "slug": "ift74",
        "symbol": "IFT74",
        "hgnc": "HGNC:21424",
        "name": "intraflagellar transport 74",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ift74"
      },
      {
        "slug": "ssx1",
        "symbol": "SSX1",
        "hgnc": "HGNC:11335",
        "name": "SSX family member 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ssx1"
      },
      {
        "slug": "stk33",
        "symbol": "STK33",
        "hgnc": "HGNC:14568",
        "name": "serine/threonine kinase 33",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stk33"
      },
      {
        "slug": "wdr19",
        "symbol": "WDR19",
        "hgnc": "HGNC:18340",
        "name": "WD repeat domain 19",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wdr19"
      },
      {
        "slug": "ak9",
        "symbol": "AK9",
        "hgnc": "HGNC:33814",
        "name": "adenylate kinase 9",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ak9"
      },
      {
        "slug": "ccdc34",
        "symbol": "CCDC34",
        "hgnc": "HGNC:25079",
        "name": "coiled-coil domain containing 34",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccdc34"
      }
    ]
  }
}