Tratto
Honeycomb lung
Honeycombing represents destroyed and fibrotic lung tissue containing numerous cystic airspaces with thick fibrous walls, representing the late stage of various lung diseases, with complete loss of acinar architecture. The cysts range in size from a few millimeters to several centimeters in diameter, have variable wall thickness, and are lined by metaplastic bronchiolar epithelium. On chest radiographs, honeycombing appears as closely approximated ring shadows, typically 3-10 mm in diameter with walls 1-3 mm in thickness, that resemble a honeycomb; the finding implies end-stage lung disease. On CT scans, the appearance is of clustered cystic air spaces, typically of comparable diameters on the order of 3-10 mm but occasionally as large as 2.5 cm. Honeycombing is usually subpleural and is characterized by well-defined walls. It is a CT feature of established pulmonary fibrosis. Because honeycombing is often considered specific for pulmonary fibrosis and is an important criterion in the diagnosis of usual interstitial pneumonia, the term should be used with care, as it may directly impact patient care.
Riepilogo
- Detto anche
- Honeycomb cysts, Honeycombing
- Sistema corporeo
- Abnormality of the respiratory system
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Dante Labs condition reports look at the genes behind groups of inherited conditions, read from one whole-genome test. Each page says which conditions and genes a report covers, how it is read and what it cannot tell you.
- Familial Pulmonary FibrosisReads 5 of these genesPARNRTEL1SFTPA1SFTPA2TERTAbout this report →
- Dyskeratosis CongenitaReads 5 of these genesPARNRTEL1STN1TERCTERTAbout this report →
- Surfactant Metabolism DysfunctionReads 2 of these genesABCA3SFTPCAbout this report →
- Inherited Predisposition to Acute Myeloid LeukaemiaReads 2 of these genesTERCTERTAbout this report →
Show 9 more reports
- Arrhythmogenic CardiomyopathyReads 1 of these genesDSPAbout this report →
- Epidermolysis BullosaReads 1 of these genesDSPAbout this report →
- Pelizaeus-Merzbacher Disease & Hypomyelinating LeukodystrophiesReads 1 of these genesATP11AAbout this report →
- VitreoretinopathyReads 1 of these genesSTN1About this report →
- Hereditary Palmoplantar Keratodermas and Pachyonychia CongenitaReads 1 of these genesDSPAbout this report →
- Other Inherited LeukodystrophiesReads 1 of these genesATP11AAbout this report →
- Hearing Loss and DeafnessReads 1 of these genesATP11AAbout this report →
- Other Inborn Errors of ImmunityReads 1 of these genesDPP9About this report →
- Inherited Neurodegenerative DisordersReads 1 of these genesATP11AAbout this report →
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Ottieni il mio Genome Test14 geni collegati a Honeycomb lung
Alterazioni in questi geni causano malattie rare in cui si osserva Honeycomb lung. La maggior parte delle persone con questo tratto non presenta nessuna di tali condizioni, e un gene di questo elenco non dice nulla sul genoma di nessuno in particolare.
| Gene | Frequenza di osservazione | Condizioni |
|---|---|---|
| ABCA3ATP binding cassette subfamily A member 3 | Spesso (30–79%) | In 2 condizioni |
| ATP11AATPase phospholipid transporting 11A | Spesso (30–79%) | In 1 condizione |
| DPP9dipeptidyl peptidase 9 | Spesso (30–79%) | In 1 condizione |
| DSPdesmoplakin | Spesso (30–79%) | In 1 condizione |
| FAM13Afamily with sequence similarity 13 member A | Spesso (30–79%) | In 1 condizione |
| MUC5Bmucin 5B, oligomeric mucus/gel-forming | Spesso (30–79%) | In 1 condizione |
| PARNpoly(A)-specific ribonuclease | Spesso (30–79%) | In 2 condizioni |
| RTEL1regulator of telomere elongation helicase 1 | Spesso (30–79%) | In 1 condizione |
| SFTPA1surfactant protein A1 | Spesso (30–79%) | In 1 condizione |
| SFTPA2surfactant protein A2 | Spesso (30–79%) | In 1 condizione |
| SFTPCsurfactant protein C | Spesso (30–79%) | In 1 condizione |
| STN1STN1 subunit of CST complex | Spesso (30–79%) | In 1 condizione |
| TERCtelomerase RNA component | Spesso (30–79%) | In 1 condizione |
| TERTtelomerase reverse transcriptase | Spesso (30–79%) | In 1 condizione |
Con quale frequenza questo tratto si presenta tra le persone con una delle condizioni legate al gene, nella misura più alta riscontrata tra queste, secondo quanto registrato dall'Human Phenotype Ontology. Queste pagine descrivono tratti e la ricerca che li riguarda; non costituiscono una diagnosi, e per i sintomi il medico o il consulente genetico è la persona a cui rivolgersi.
Tratti più generali
Fonte dei dati
- Human Phenotype Ontology, versione 2026-09-01: il tratto, i suoi nomi, la sua definizione e i geni a esso collegati. Per saperne di più visiti hpo.jax.org.
- Versione dei dati 2026.10.19-9814e911.
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