Traits

Traits linked to TRANK1

tetratricopeptide repeat and ankyrin repeat containing 1

The Human Phenotype Ontology links 35 traits to TRANK1, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Cognitive impairment	Very often (80–99%)
Confusion	Very often (80–99%)
Episodic hypersomnia	Very often (80–99%)
Abnormal brain FDG positron emission tomography	Often (30–79%)
Abnormal eating behavior	Often (30–79%)
Abnormal speech pattern	Often (30–79%)
Agitation	Often (30–79%)
Amplification of sexual behavior	Often (30–79%)
Anxiety	Often (30–79%)
Depression	Often (30–79%)
Headache	Often (30–79%)
Increased appetite	Often (30–79%)
Irritability	Often (30–79%)
Lack of feeling, emotion, interest	Often (30–79%)
Poor hand-eye coordination	Often (30–79%)
Repetitive compulsive behavior	Often (30–79%)
Transient global amnesia	Often (30–79%)
Delusions	Sometimes (5–29%)
Derealization	Sometimes (5–29%)
Extreme thirst	Sometimes (5–29%)
Hypnagogic hallucination	Sometimes (5–29%)
Inability to speak	Sometimes (5–29%)
Sleep paralysis	Sometimes (5–29%)
Slurred speech	Sometimes (5–29%)
Sweet craving	Sometimes (5–29%)

Abnormality of head or neck

Trait	How often it is seen
Altered sense of taste	Often (30–79%)
Parosmia	Often (30–79%)

Abnormality of the digestive system

Trait	How often it is seen
Nausea	Sometimes (5–29%)
Poor appetite	Sometimes (5–29%)

Abnormality of the eye

Trait	How often it is seen
Extreme sensitivity of the eyes to light	Often (30–79%)
Blurred vision	Sometimes (5–29%)

Abnormality of the genitourinary system

Trait	How often it is seen
Decreased libido	Sometimes (5–29%)

Abnormality of the integument

Trait	How often it is seen
Excessive sweating	Often (30–79%)

Constitutional symptom

Trait	How often it is seen
Hot flashes	Sometimes (5–29%)

Laboratory abnormality

Trait	How often it is seen
Fever	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to TRANK1 and how often each is seen. Find out more at hpo.jax.org.

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test