Traits

Traits linked to TANC2

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2

The Human Phenotype Ontology links 18 traits to TANC2, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Delayed speech and language development	Very often (80–99%)
Intellectual disability	Very often (80–99%)
Anxiety	Often (30–79%)
Autism spectrum disorder	Often (30–79%)
Difficulty sleeping	Often (30–79%)
Epilepsy	Often (30–79%)
Motor delay	Often (30–79%)
Repetitive movements	Often (30–79%)
Spastic ataxia	Often (30–79%)
Attention deficit	Sometimes (5–29%)
Loss of developmental milestones	Sometimes (5–29%)

Abnormality of head or neck

Trait	How often it is seen
Abnormally small head	Sometimes (5–29%)
Deformity of the skull	Sometimes (5–29%)
Widely spaced teeth	Not recorded

Abnormality of the musculoskeletal system

Trait	How often it is seen
Double-Jointed	Often (30–79%)
Generalized decreased muscle tone	Often (30–79%)
Scoliosis	Not recorded

Abnormality of the digestive system

Trait	How often it is seen
Chronic constipation	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to TANC2 and how often each is seen. Find out more at hpo.jax.org.

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