Traits

Traits linked to RNF43

ring finger protein 43

The Human Phenotype Ontology links 15 traits to RNF43, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the digestive system

Trait	How often it is seen
Colorectal polyposis	Very often (80–99%)
Adenomatous colonic polyposis	Often (30–79%)
Gastric diverticulum	Often (30–79%)
Large intestine tumor	Sometimes (5–29%)
Biliary tract neoplasm	Rarely (1–4%)
Pancreatic adenocarcinoma	Rarely (1–4%)
Serrated intestinal polyps	Not recorded

Abnormality of the genitourinary system

Trait	How often it is seen
Bladder carcinoma	Rarely (1–4%)
Germ cell neoplasia	Rarely (1–4%)
Ovarian cancer	Rarely (1–4%)
Prostate cancer	Rarely (1–4%)

Abnormal tissue mass

Trait	How often it is seen
Cancer of skin pigment cells	Rarely (1–4%)

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Hodgkin lymphoma	Rarely (1–4%)

Abnormality of the breast

Trait	How often it is seen
Breast cancer	Rarely (1–4%)

Abnormality of the nervous system

Trait	How often it is seen
Schwannoma	Rarely (1–4%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to RNF43 and how often each is seen. Find out more at hpo.jax.org.

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