Traits

Traits linked to PIGK

phosphatidylinositol glycan anchor biosynthesis class K

The Human Phenotype Ontology links 15 traits to PIGK, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of head or neck

Trait	How often it is seen
Dental crowding	Not recorded
High frontal hairline	Not recorded
Limited hair on end of eyebrow	Not recorded
Long face	Not recorded
Prominent forehead	Not recorded
Thin red part of the upper lip	Not recorded

Abnormality of the nervous system

Trait	How often it is seen
Global developmental delay	Always
Degeneration of cerebellum	Very often (80–99%)
Ataxia	Often (30–79%)
Epilepsy	Often (30–79%)

Abnormal cellular phenotype

Trait	How often it is seen
Decreased expression of GPI-anchored proteins on the cell surface	Not recorded

Abnormality of limbs

Trait	How often it is seen
Short fingers or toes	Not recorded

Abnormality of the ear

Trait	How often it is seen
Prominent antitragus	Not recorded

Abnormality of the musculoskeletal system

Trait	How often it is seen
Generalized decreased muscle tone	Always

Laboratory abnormality

Trait	How often it is seen
Decreased serum alkaline phosphatase	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to PIGK and how often each is seen. Find out more at hpo.jax.org.

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